Gene Symbol | LARS |
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Entrez Gene | 51520 |
Alt Symbol | HSPC192, ILFS1, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl |
Species | Human |
Gene Type | protein-coding |
Description | leucyl-tRNA synthetase |
Other Description | cytoplasmic leucyl-tRNA synthetase|cytosolic leucyl-tRNA synthetase|leucine tRNA ligase 1, cytoplasmic|leucine translase|leucine--tRNA ligase, cytoplasmic|leucine-tRNA ligase|leucyl-tRNA synthetase, cytoplasmic|proliferation-inducing gene 44 |
Swissprots | Q9NSE1 Q9P2J5 A7E266 A2RRR4 Q2TU79 B4DJ10 |
Accessions | EAW61848 EAW61849 EAW61850 Q9P2J5 AB037773 BAA92590 AF151026 AAF36112 AK000277 AK001457 BAA91702 AK001682 BAA91833 AK021413 BAB13817 AK023777 BAB14674 AK025441 AK095870 AK127009 BAG54421 AK225372 AK293750 BAG57172 AK295874 BAG58672 AK304134 BAG65028 AK315178 BAG37619 AL390155 CAB99091 AY513284 AAT08037 AY926480 AAX10025 BC068041 AAH68041 BC105581 AAI05582 BC110084 BC131798 AAI31799 BC150213 AAI50214 BC151214 AAI51215 BC152422 AAI52423 CK902545 D84223 BAA95667 DB086913 U56252 XM_011537655 XP_011535957 XM_011537656 XP_011535958 XM_011537657 XP_011535959 NM_020117 NP_064502 |
Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. {ECO:0000269|PubMed:19426743}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Aminoacyl-tRNA biosynthesis |
LeuRS CRISPR/Cas9 KO Plasmid (h) - sc-404485 from Santa Cruz Biotechnology
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LeuRS HDR Plasmid (h) - sc-404485-HDR from Santa Cruz Biotechnology
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LeuRS Double Nickase Plasmid (h) - sc-404485-NIC from Santa Cruz Biotechnology
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LeuRS Double Nickase Plasmid (h2) - sc-404485-NIC-2 from Santa Cruz Biotechnology
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LeuRS CRISPR Activation Plasmid (h) - sc-404485-ACT from Santa Cruz Biotechnology
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LeuRS CRISPR Activation Plasmid (h2) - sc-404485-ACT-2 from Santa Cruz Biotechnology
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LeuRS Lentiviral Activation Particles (h) - sc-404485-LAC from Santa Cruz Biotechnology
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LeuRS Lentiviral Activation Particles (h2) - sc-404485-LAC-2 from Santa Cruz Biotechnology
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LeuRS siRNA (h) - sc-75416 from Santa Cruz Biotechnology
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LeuRS shRNA Plasmid (h) - sc-75416-SH from Santa Cruz Biotechnology
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LeuRS shRNA (h) Lentiviral Particles - sc-75416-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU099721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11556 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11556 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08037 from Sigma-Aldrich
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LARS siRNA (Human) - CRH9806 from Cohesion Biosciences
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shRNA set against Human LARS (NM_020117.9) - SHH328563 from Creative biogene
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shRNA set against Human LARS(NM_020117.9) - SHH142625 from Creative biogene
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LARS shRNA Plasmid (Human) - CHH9806 from Cohesion Biosciences
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LARS miRNA 3'UTR clone - MiUTR1H-05578 from Creative biogene
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