Gene Symbol | H2BFWT |
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Entrez Gene | 158983 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | H2B histone family, member W, testis-specific |
Other Description | histone H2B type W-T |
Swissprots | B1AK72 Q7Z2G1 Q147W3 |
Accessions | AAP37489 CAI43100 EAX02765 EAX02766 Q7Z2G1 AY283370 AAP37490 BC038109 AAH38109 BC118604 AAI18605 BC121816 AAI21817 NM_001002916 NP_001002916 |
Function | Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. {ECO:0000269|PubMed:16449661}. |
Subcellular Location | Nucleus membrane {ECO:0000269|PubMed:15475252}. Chromosome {ECO:0000269|PubMed:15475252}. |
Tissue Specificity | Testis-specific. Present in sperm cells (at protein level). {ECO:0000269|PubMed:15475252}. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |
H2BFWT CRISPR/Cas9 KO Plasmid (h) - sc-407111 from Santa Cruz Biotechnology
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H2BFWT HDR Plasmid (h) - sc-407111-HDR from Santa Cruz Biotechnology
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H2BFWT Double Nickase Plasmid (h) - sc-407111-NIC from Santa Cruz Biotechnology
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H2BFWT Double Nickase Plasmid (h2) - sc-407111-NIC-2 from Santa Cruz Biotechnology
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H2BFWT CRISPR Activation Plasmid (h) - sc-407111-ACT from Santa Cruz Biotechnology
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H2BFWT CRISPR Activation Plasmid (h2) - sc-407111-ACT-2 from Santa Cruz Biotechnology
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H2BFWT Lentiviral Activation Particles (h) - sc-407111-LAC from Santa Cruz Biotechnology
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H2BFWT Lentiviral Activation Particles (h2) - sc-407111-LAC-2 from Santa Cruz Biotechnology
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H2BFWT siRNA (h) - sc-91226 from Santa Cruz Biotechnology
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H2BFWT shRNA Plasmid (h) - sc-91226-SH from Santa Cruz Biotechnology
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H2BFWT shRNA (h) Lentiviral Particles - sc-91226-V from Santa Cruz Biotechnology
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H2BFWT RNAi - H00158983-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9846 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9846 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02854 from Sigma-Aldrich
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H2BFWT siRNA (Human) - CRJ5883 from Cohesion Biosciences
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H2BFWT - MBS8235621 from MyBioSource
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H2BFWT CRISPR/Cas9 KO Plasmid (h2) - sc-407111-KO-2 from Santa Cruz Biotechnology
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H2BFWT HDR Plasmid (h2) - sc-407111-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human H2BFWT (NM_001002916.3) - SHH309906 from Creative biogene
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Human H2BFWT siRNA - orb276384 from Biorbyt
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H2BFWT shRNA Plasmid (Human) - CHJ5883 from Cohesion Biosciences
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H2BFWT miRNA 3'UTR clone - MiUTR4H-TG11397 from Creative biogene
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