| Gene Symbol |
POLD1
|
| Entrez Gene |
5424
|
| Alt Symbol |
CDC2, CRCS10, MDPL, POLD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (DNA directed), delta 1, catalytic subunit
|
| Other Description |
CDC2 homolog|DNA polymerase delta catalytic subunit|DNA polymerase subunit delta p125|polymerase (DNA directed), delta 1, catalytic subunit 125kDa
|
| Swissprots |
Q96H98 P28340 Q8NER3
|
| Accessions |
AAM76971 EAW71856 EAW71857 P28340 AA236879 AB209560 BAD92797 BC008800 AAH08800 BM193218 CD101690 DQ234348 ABB29977 DQ895953 ABM86879 EU176381 ABW03832 M80397 AAA58439 M81735 AAA35768 XM_005259008 XP_005259065 XM_011527038 XP_011525340 XM_011527039 XP_011525341 XR_935835 NM_001256849 NP_001243778 NM_001308632 NP_001295561 NM_002691 NP_002682 NR_046402
|
| Function |
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed across a panel of tissues, with high levels of expression in heart and lung. {ECO:0000269|PubMed:23770608}.
|
| Top Pathways |
HTLV-I infection, Nucleotide excision repair, Base excision repair, Homologous recombination, Mismatch repair
|