POLD1

Gene Symbol	POLD1
Entrez Gene	5424
Alt Symbol	CDC2, CRCS10, MDPL, POLD
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed), delta 1, catalytic subunit
Other Description	CDC2 homolog|DNA polymerase delta catalytic subunit|DNA polymerase subunit delta p125|polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Swissprots	Q96H98 P28340 Q8NER3
Accessions	AAM76971 EAW71856 EAW71857 P28340 AA236879 AB209560 BAD92797 BC008800 AAH08800 BM193218 CD101690 DQ234348 ABB29977 DQ895953 ABM86879 EU176381 ABW03832 M80397 AAA58439 M81735 AAA35768 XM_005259008 XP_005259065 XM_011527038 XP_011525340 XM_011527039 XP_011525341 XR_935835 NM_001256849 NP_001243778 NM_001308632 NP_001295561 NM_002691 NP_002682 NR_046402
Function	Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
Subcellular Location	Nucleus.
Tissue Specificity	Expressed across a panel of tissues, with high levels of expression in heart and lung. {ECO:0000269|PubMed:23770608}.
Top Pathways	HTLV-I infection, Nucleotide excision repair, Base excision repair, Homologous recombination, Mismatch repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNA pol δ cat siRNA (h) - sc-37777 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNA pol δ cat shRNA Plasmid (h) - sc-37777-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNA pol δ cat shRNA (h) Lentiviral Particles - sc-37777-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNA Polymerase delta, catalytic subunit RNAi - H00005424-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU131101 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2106 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2106 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

POLD1 siRNA (Human) - CRH3627 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human POLD1 (NM_002691.3) - SHH379092 from Creative biogene Category siRNA Species Reactivities Human

POLD1 shRNA Plasmid (Human) - CHH3627 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

POLD1 miRNA 3'UTR clone - MiUTR3H-01789 from Creative biogene Species Reactivities Human

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