APLP2

Gene Symbol APLP2
Entrez Gene 334
Alt Symbol APLP-2, APPH, APPL2, CDEBP
Species Human
Gene Type protein-coding
Description amyloid beta (A4) precursor-like protein 2
Other Description CDEI box-binding protein|amyloid precursor protein homolog HSD-2|amyloid-like protein 2
Swissprots B3KXX9 Q13861 Q14594 Q9BT36 Q71U10 Q06481 H7BXI4 Q14662 Q7M4L3
Accessions BAA34958 CCQ43109 EAW67768 EAW67769 EAW67770 EAW67771 EAW67772 EAW67773 EAW67774 Q06481 AF168956 AAD47291 AK056883 AK122834 AK124457 AK128162 BAG54641 AK225283 AK296765 BAG59345 AK300378 BAG62113 AK304736 BAG65497 AK308248 AK308932 BC000373 AAH00373 BC004371 AAH04371 BM992563 BX647107 DC336210 EU176299 ABW03750 EU176627 ABW03428 L09209 AAA35526 L19597 AAA35601 L23113 AAA36032 L23114 AAA36130 L27631 AAC41701 S60099 AAC60589 Z22572 CAA80295 NM_001142276 NP_001135748 NM_001142277 NP_001135749 NM_001142278 NP_001135750 NM_001243299 NP_001230228 NM_001642 NP_001633 NR_024515 NR_024516
Function May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.
Tissue Specificity Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

APLP2 (C-17) - sc-23822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APLP2 (C-17): sc-23822. Western blot analysis of APLP2 expression in mouse brain tissue extract.

APLP2 (V-20) - sc-23821 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-APLP2 (phospho Y755) antibody - ab193672 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue sections labeling APLP2 (phospho Y755) with ab193672 at a 1/50 dilution. The image on the right was preincubated with blocking peptide.

Anti-APLP2 antibody - ab128603 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab128603 stained DU145 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab128603 at 5 ug/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-APLP2 antibody - ab196894 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-APLP2 antibody (ab196894) at 1/500 dilutionLane 1 : Extracts from rat brain cellsLane 2 : Extracts from rat brain cells with synthetic peptide

Anti-APLP2 antibody - ab109996 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-APLP2 antibody (ab109996) at 1/500 dilutionLane 1 : A549 cellsLane 2 : RAW264.7 cellsLane 3 : A549 with synthesized peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-APLP2 antibody [EPR5938(2)] - ab140624 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5938(2)
Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling APLP2 with ab140624 at 1/100 dilution.

Anti-APLP2 antibody - C-terminal - ab190925 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-APLP2 antibody - C-terminal (ab190925) at 0.5 µg/mlLane 1 : Rat brain tissue lysateLane 2 : Rat heart tissue lysateLane 3 : SMMC cell lysate

Anti-APLP2 antibody - N-terminal - ab137597 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa30-680, clone 11n11) - LS-C184177 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11n11

Anti-APLP2 Antibody (Tyr274) - LS-C192110 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa241-290) - LS-C119722 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from RAW264.7/A549 cells, using APLP2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-APLP2 Antibody (aa593-621, AP) - LS-C251531 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa593-621, APC) - LS-C251532 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa593-621, Biotin) - LS-C251533 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa593-621, PE) - LS-C251535 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa593-621, FITC) - LS-C251534 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa593-621, Azide-free, HRP) - LS-C251536 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (phospho-Tyr755) - LS-C198636 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using APLP2 (Phospho-Tyr755) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-APLP2 Antibody (clone 4B5) - LS-C196669 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B5
Detection limit for recombinant GST tagged APLP2 is approximately 1 ng/ml as a capture antibody.

Anti-APLP2 Antibody - LS-C309469 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa262-491) - LS-C179025 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa592-621) - LS-C319538 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APLP2 Antibody (aa714-763) - LS-C198635 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from rat brain, using APLP2 Antibody. The lane on the right was incubated with synthetic peptide.

Anti-APLP2 Antibody (Internal) - LS-C345310 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of APLP2 Antibody with human ACHN Whole Cell lysate.
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