| Gene Symbol |
APLP2
|
| Entrez Gene |
334
|
| Alt Symbol |
APLP-2, APPH, APPL2, CDEBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
amyloid beta (A4) precursor-like protein 2
|
| Other Description |
CDEI box-binding protein|amyloid precursor protein homolog HSD-2|amyloid-like protein 2
|
| Swissprots |
B3KXX9 Q13861 Q14594 Q9BT36 Q71U10 Q06481 H7BXI4 Q14662 Q7M4L3
|
| Accessions |
BAA34958 CCQ43109 EAW67768 EAW67769 EAW67770 EAW67771 EAW67772 EAW67773 EAW67774 Q06481 AF168956 AAD47291 AK056883 AK122834 AK124457 AK128162 BAG54641 AK225283 AK296765 BAG59345 AK300378 BAG62113 AK304736 BAG65497 AK308248 AK308932 BC000373 AAH00373 BC004371 AAH04371 BM992563 BX647107 DC336210 EU176299 ABW03750 EU176627 ABW03428 L09209 AAA35526 L19597 AAA35601 L23113 AAA36032 L23114 AAA36130 L27631 AAC41701 S60099 AAC60589 Z22572 CAA80295 NM_001142276 NP_001135748 NM_001142277 NP_001135749 NM_001142278 NP_001135750 NM_001243299 NP_001230228 NM_001642 NP_001633 NR_024515 NR_024516
|
| Function |
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
|
