CCNE1

Gene Symbol CCNE1
Entrez Gene 898
Alt Symbol CCNE
Species Human
Gene Type protein-coding
Description cyclin E1
Other Description G1/S-specific cyclin-E1|cyclin E variant ex5del|cyclin E variant ex7del|cyclin Es|cyclin Et
Swissprots Q14091 P24864 Q9UD21 A8K684 Q92501 Q8NFG1
Accessions AAM54043 AEF32520 CAA64687 CAA64688 P24864 AK291549 BAF84238 AU137789 BC035498 AAH35498 BE645164 DQ893383 ABM84309 DQ896703 ABM87702 KF672847 AHC02488 KF672848 AHC02489 M73812 M74093 XM_005259370 XP_005259427 XM_006723457 XP_006723520 XM_011527440 XP_011525742 NM_001238 NP_001229 NM_057182
Function Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
Subcellular Location Nucleus {ECO:0000269|PubMed:7739542}.
Tissue Specificity Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. {ECO:0000269|PubMed:9840943}.
Top Pathways Oocyte meiosis, Cell cycle, Measles, Viral carcinogenesis, PI3K-Akt signaling pathway

Phospho-Cyclin E1 (Thr62) Antibody - 4136 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, treated with 10 mM LiCl for the indicated times, using Phospho-Cyclin E1 (Thr62) Antibody (upper) or a cyclin E antibody (lower).

Cyclin E1 (HE12) Mouse mAb - 4129 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone HE12
Western blot analysis of extracts from various cell types using Cyclin E (HE12) Mouse mAb.

Cyclin E1 Antibody - 2925 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

cyclin E (B-7) - sc-48420 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin E (B-7): sc-48420. Western blot analysis of cyclin E expression in non-transfected: sc-117752 (A) and human cyclin E transfected: sc-170464 (B) 293T whole cell lysates.

cyclin E (M-20) - sc-481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin E (M-20): sc-481. Western blot analysis of cyclin E1 expression in phorbol ester-induced KNRK (A) and 3611-RF (B) nuclear extracts.

cyclin E (HE12) - sc-247 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin E (HE12): sc-247. Western blot analysis of cyclin E expression in K-562 (A) and Jurkat (B,C) nuclear extracts.

cyclin E (E-4) - sc-377100 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin E (E-4): sc-377100. Western blot analysis of cyclin E expression in K-562 nuclear extract.

cyclin E (C-19) - sc-198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin E (C-19): sc-198. Western blot analysis of cyclin E expression in K-562 (A) and Jurkat (B) nuclear extracts.

cyclin E (HE111) - sc-248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of cyclin E expression in MEG-01 whole cell lysate immunoprecipitated with cyclin E (HE111): sc-248 and detected with cyclin E (C-19): sc-198.

cyclin E (H-145) - sc-20684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin E (H-145): sc-20684. Western blot analysis of cyclin E expression in K-562 (A) and JEG-3 (B) whole cell lysates.

cyclin E (13A3) - sc-56310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl supernatant
Host Mouse
Clonality Monoclonal
cyclin E (13A3): sc-56310. Western blot analysis of cyclin E expression in MOLT-4 (A), K-562 (B), HeLa (C) and IMR-32 (D) nuclear extracts and MEG-01 (E) and JEG-3 (F) whole cell lysates.

Anti-Cyclin E1 (phospho T395) antibody - ab52195 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin E1 (phospho T395) antibody (ab52195) at 1/500 dilutionLane 1 : HeLa cells treated with Paclitaxel 1uM 60 minutes with phospho peptideLane 2 : HeLa cells treated with Paclitaxel 1uM 60 minutes with phospho peptide

Anti-Cyclin E1 (phospho T395) antibody - ab195979 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin E1 (phospho T395) antibody (ab195979) at 1/500 dilutionLane 1 : Whole lysate of HeLa cells treated with paclitaxel with the antigen-specific peptideLane 2 : Whole lysate of HeLa cells treated with paclitaxelLysates/proteins at 12.5 µg per lane.

Anti-Cyclin E1 (phospho T395) antibody - ab194876 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin E1 (phospho T395) antibody (ab194876) at 1/500 dilutionLane 1 : Extract from 293 cells, untreatedLane 2 : Extract from 293 cells treated with hydroxyurea

Anti-Cyclin E1 (phospho T77) antibody - ab62199 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells using ab62199 at a dilution of 1/500. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

Anti-Cyclin E1 (phospho T77) antibody [EPR2242(2)] - ab124696 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2242(2)
All lanes : Anti-Cyclin E1 (phospho T77) antibody [EPR2242(2)] (ab124696) at 1/1000 dilutionLane 1 : JAR cell lysate, untreatedLane 2 : JAR cell lysate, treated with Lambda PhosphataseLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Cyclin E1 antibody - ab7959 from Abcam

Prices $400.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of Human corneal endothelial cells, staining Cyclin E with ab7959.Cells were fixed with methanol, permeabilized with n.a and blocked with serum for 30 minutes at 37°C. Samples were incubated with primary antibody (1:200 in 2% BSA + 2% goat serum) for 1 hour at 37°C. An undiluted AlexaFluor®555-conjugated goat anti-rabbit polyclonal IgG (ab150078) was used as the secondary antibody.See Abreview

Anti-Cyclin E1 antibody - ab88259 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Cyclin E staining in Human normal placenta formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab88259, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Cyclin E1 antibody - ab52189 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin E1 antibody (ab52189) at 1/500 dilutionLane 1 : extracts from HeLa cells, treated with Paclitasel (1uM, 60mins)Lane 2 : extracts from HeLa cells, treated with Paclitasel (1uM, 60mins) with blocking peptide

Anti-Cyclin E1 antibody - ab2094 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cyclin E1 antibody - ab71535 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC image of Cyclin E staining in Human cerebral cortex formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab71535, 1/200 dilution, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Cyclin E1 antibody - ab74276 from Abcam

Prices $378.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab74276, at 1/50 dilution, staining Cyclin E in formalin-fixed, paraffin-embedded human breast carcinoma tissue by Immunohistochemistry.

Anti-Cyclin E1 antibody - ab62624 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human heart tissue, using ab62624 at 1/50 dilution. The picture on the right is blocked with the synthesized peptide.

Anti-Cyclin E1 antibody - ab89585 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Cyclin E1 antibody (ab89585) at 1 µg/ml + Human colon tissue lysate at 50 µg

Anti-Cyclin E1 antibody - ab52239 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin E1 antibody (ab52239) at 1/300 dilutionLane 1 : K562 cell extract; without peptideLane 2 : K562 cell extract; with peptide
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