| Gene Symbol |
FOXP1
|
| Entrez Gene |
27086
|
| Alt Symbol |
12CC4, HSPC215, MFH, QRF1, hFKH1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box P1
|
| Other Description |
fork head-related protein like B|forkhead box protein P1|glutamine-rich factor 1|mac-1-regulated forkhead
|
| Swissprots |
Q9BSG9 Q9H332 B3KV70 Q8NAN6 G5E9V8 Q9P0R1 Q9H334 Q9H333
|
| Accessions |
CAH05290 CAH05291 CDI30172 EAW65489 EAW65490 EAW65491 EAW65492 EAW65493 EAW65494 EAW65495 EAW65496 EAW65497 EAW65498 EAW65499 EAW65500 Q9H334 AA380962 AB052767 BAC53800 AF146696 AAG47632 AF151049 AAF36135 AF250920 AAL56661 AF275309 AAK69408 AK026898 AK027264 BAB55005 AK074321 BAB85050 AK074569 BAC11065 AK092383 BAC03875 AK122710 BAG53682 AK297649 BAG60016 BC005055 AAH05055 BC054505 BC054815 AAH54815 BC068481 BC071893 AAH71893 BC080521 AAH80521 BC131720 AAI31721 BC152752 AAI52753 BT006643 AAP35289 BX647682 CR457164 CAG33445 DA518749 DA634017 GD144178 KC551794 KC551795 LK937714 XM_005264735 XP_005264792 XM_005264736 XP_005264793 XM_005264737 XP_005264794 XM_005264742 XP_005264799 XM_006713102 XP_006713165 XM_006713103 XP_006713166 XM_006713104 XP_006713167 XM_011533584 XP_011531886 XM_011533585 XP_011531887 XM_011533586 XP_011531888 XM_011533587 XP_011531889 XM_011533588 XP_011531890 XR_427266 XR_940413 XR_940414 NM_001012505 NP_001012523 NM_001244808 NP_001231737 NM_001244810 NP_001231739 NM_001244812 NP_001231741 NM_001244813 NP_001231742 NM_001244814 NP_001231743 NM_001244815 NP_001231744 NM_001244816 NP_001231745 NM_032682 NP_116071
|
| Function |
Transcriptional repressor (PubMed:18347093). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neu
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:25027557}.
|
| Tissue Specificity |
Isoform 8 is specifically expressed in embryonic stem cells. {ECO:0000269|PubMed:21924763}.
|
| Top Pathways |
MicroRNAs in cancer
|