| Gene Symbol |
Dhfr
|
| Entrez Gene |
13361
|
| Alt Symbol |
8430436I03Rik, AA607882, AI662710, AW555094
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
dihydrofolate reductase
|
| Other Description |
-
|
| Swissprots |
Q61485 P00375 Q61579 P70693 Q61487
|
| Accessions |
AAA37637 AAA37638 AAO26057 CAA24111 CAP58632 CAX23887 EDL00958 P00375 AI854085 AK018462 AK031241 BAC27315 AK136212 BAE22879 BC005796 AAH05796 BU058996 CB247191 L26316 AAA37523 M10722 AAA37524 M10811 AAA37525 V00731 CAB43539 V00732 V00734 CAA24112 X56066 CAA39544 NM_010049 NP_034179
|
| Function |
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
|
| Top Pathways |
Folate biosynthesis, One carbon pool by folate
|