| Gene Symbol | IL17RD |
|---|---|
| Entrez Gene | 54756 |
| Alt Symbol | HH18, IL-17RD, IL17RLM, SEF |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 17 receptor D |
| Other Description | IL-17 receptor D|IL17Rhom|hSef|interleukin-17 receptor D|interleukin-17 receptor-like protein|sef homolog |
| Swissprots | Q8NFM7 Q8NFS0 Q6UWI5 Q58EZ7 Q6RVF4 Q2NKP7 Q8N113 Q9UFA0 |
| Accessions | EAW65329 EAW65330 Q8NFM7 AF458067 AAM77571 AF494208 AAM74077 AF494211 AAM74080 AK001251 AK092579 AK093074 AK125591 AK302045 BAG63437 AL133097 CAB61408 AL833913 CAD38769 AY358774 AAQ89134 AY489047 AAS15051 BC038369 BC111702 AAI11703 BF803798 BQ017683 CN302483 XM_005265238 XP_005265295 XM_006713209 XP_006713272 XM_011533849 XP_011532151 XM_011533850 XP_011532152 NM_017563 NP_060033 |
| Function | Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Cell membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation. |
| Tissue Specificity | Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells. {ECO:0000269|PubMed:12807873}. |