IL17RD

Gene Symbol	IL17RD
Entrez Gene	54756
Alt Symbol	HH18, IL-17RD, IL17RLM, SEF
Species	Human
Gene Type	protein-coding
Description	interleukin 17 receptor D
Other Description	IL-17 receptor D|IL17Rhom|hSef|interleukin-17 receptor D|interleukin-17 receptor-like protein|sef homolog
Swissprots	Q8NFM7 Q8NFS0 Q6UWI5 Q58EZ7 Q6RVF4 Q2NKP7 Q8N113 Q9UFA0
Accessions	EAW65329 EAW65330 Q8NFM7 AF458067 AAM77571 AF494208 AAM74077 AF494211 AAM74080 AK001251 AK092579 AK093074 AK125591 AK302045 BAG63437 AL133097 CAB61408 AL833913 CAD38769 AY358774 AAQ89134 AY489047 AAS15051 BC038369 BC111702 AAI11703 BF803798 BQ017683 CN302483 XM_005265238 XP_005265295 XM_006713209 XP_006713272 XM_011533849 XP_011532151 XM_011533850 XP_011532152 NM_017563 NP_060033
Function	Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). {ECO:0000250}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Cell membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.
Tissue Specificity	Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells. {ECO:0000269|PubMed:12807873}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL17RD protein fragment - ab153382 from Abcam Category Protein Source Wheat germ Species Human

IL17RD Antibody Blocking Peptide - LS-E22596 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL17RD Antibody Blocking Peptide - LS-E10235 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-17 RD/SEF Protein - H00054756-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IL17RD-Antibody-N-term-Blocking-Peptide - BP9631a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IL-17 RD/SEF - 2275-IL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala27-Arg299, with a C-terminal 6-His tag

Recombinant Human IL-17 RD/SEF, CF - 2275-IL-050/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala27-Arg299, with a C-terminal 6-His tag

Human IL 17RD protein - orb83038 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Canine IL-17RD (Fc Tag) protein - orb232680 from Biorbyt Category Protein Prices $357.00, $570.00 Sizes 10 μg, 50 μg Species Dog

Human IL17RD Protein - abx067469 from Abbexa Category Protein Source E.coli Species Human

IL17RD - H00054756-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IL17RD - H00054756-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Interleukin 17 Receptor D (IL17RD), Human - 20-8747 from ARP American Research Products Category Protein Prices $515.00 Sizes 50 µg Source E.coli Species Human

IL17RD fusion protein - ag17286 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

IL17RD fusion protein - ag16636 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human IL17RD, His tagged - IL17RD-766H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human IL17RD, His-tagged - IL17RD-404H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Interleukin 17 Receptor D (IL17RD) - RPD349Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Interleukin 17 Receptor D (IL17RD) - RPD349Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Interleukin 17 Receptor D (IL17RD) - RPD349Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human IL17RD Protein (His Tag) - 10507-H08H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Recombinant Interleukin 17 Receptor D (IL17RD) - RPD349Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Interleukin-17 receptor D(IL17RD) - CSB-YP847706HU CSB-EP847706HU CSB-BP847706HU CSB-MP847706HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human IL-17 RD/SEF Protein - 2275-IL from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Ala27-Arg299, with a C-terminal 6-His tag Species Human

Recombinant Human IL-17 RD/SEF Protein, CF - 2275-IL/CF from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Ala27-Arg299, with a C-terminal 6-His tag Species Human

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