| Gene Symbol |
MIP
|
| Entrez Gene |
4284
|
| Alt Symbol |
AQP0, CTRCT15, LIM1, MIP26, MP26
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
major intrinsic protein of lens fiber
|
| Other Description |
aquaporin 0|lens fiber major intrinsic protein
|
| Swissprots |
Q17R41 P30301
|
| Accessions |
AAC02794 EAW96940 P30301 AK307357 BC074913 AAH74913 BC117474 AAI17475 BM696300 BM705396 BM716579 BM724221 CD675949 HQ258134 ADR82888 XM_011538354 XP_011536656 NM_012064 NP_036196
|
| Function |
Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
|
| Tissue Specificity |
Major component of lens fiber gap junctions.
|