Gene Symbol | MIP |
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Entrez Gene | 4284 |
Alt Symbol | AQP0, CTRCT15, LIM1, MIP26, MP26 |
Species | Human |
Gene Type | protein-coding |
Description | major intrinsic protein of lens fiber |
Other Description | aquaporin 0|lens fiber major intrinsic protein |
Swissprots | Q17R41 P30301 |
Accessions | AAC02794 EAW96940 P30301 AK307357 BC074913 AAH74913 BC117474 AAI17475 BM696300 BM705396 BM716579 BM724221 CD675949 HQ258134 ADR82888 XM_011538354 XP_011536656 NM_012064 NP_036196 |
Function | Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. |
Tissue Specificity | Major component of lens fiber gap junctions. |
AQP0 CRISPR/Cas9 KO Plasmid (h) - sc-403852 from Santa Cruz Biotechnology
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AQP0 HDR Plasmid (h) - sc-403852-HDR from Santa Cruz Biotechnology
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AQP0 Double Nickase Plasmid (h) - sc-403852-NIC from Santa Cruz Biotechnology
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AQP0 Double Nickase Plasmid (h2) - sc-403852-NIC-2 from Santa Cruz Biotechnology
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AQP0 CRISPR Activation Plasmid (h) - sc-403852-ACT from Santa Cruz Biotechnology
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AQP0 CRISPR Activation Plasmid (h2) - sc-403852-ACT-2 from Santa Cruz Biotechnology
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AQP0 Lentiviral Activation Particles (h) - sc-403852-LAC from Santa Cruz Biotechnology
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AQP0 Lentiviral Activation Particles (h2) - sc-403852-LAC-2 from Santa Cruz Biotechnology
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AQP0 siRNA (h) - sc-42361 from Santa Cruz Biotechnology
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AQP0 shRNA Plasmid (h) - sc-42361-SH from Santa Cruz Biotechnology
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AQP0 shRNA (h) Lentiviral Particles - sc-42361-V from Santa Cruz Biotechnology
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Aquaporin-0 RNAi - H00004284-R01 from Novus Biologicals
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MISSION® siRNA - SIHK1298 from Sigma-Aldrich
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MISSION® siRNA - SIHK1296 from Sigma-Aldrich
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MISSION® siRNA - SIHK1297 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2376 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2376 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09039 from Sigma-Aldrich
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MIP siRNA (Human) - CRH2903 from Cohesion Biosciences
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shRNA set against Human Mip (NM_012064.3) - SHH342091 from Creative biogene
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Human MIP siRNA - orb263405 from Biorbyt
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MIP shRNA Plasmid (Human) - CHH2903 from Cohesion Biosciences
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MIP miRNA 3'UTR clone - MiUTR4H-TG05527 from Creative biogene
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