| Gene Symbol |
DMAP1
|
| Entrez Gene |
55929
|
| Alt Symbol |
DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA methyltransferase 1 associated protein 1
|
| Other Description |
DNA methyltransferase 1-associated protein 1|DNMT1 associated protein 1|DNMT1-associated protein 1
|
| Swissprots |
Q0JSM4 Q9NPF5 Q9H0S8 A8K001 Q5TG41 Q7Z3H7 Q9P2C2 D3DPY8
|
| Accessions |
EAX07046 EAX07047 EAX07048 EAX07049 EAX07050 EAX07051 Q9NPF5 AB037846 BAA92663 AF265228 AAF87079 AK021605 BAB13854 AK054954 AK092898 AK096252 AK289366 BAF82055 AK293598 BAG57063 AK298793 BAG60930 AK300217 BAG61985 AK300372 BAG62108 AK300442 BAG62165 AL136657 CAB66592 AL137200 CAB69910 AM393614 CAL38490 BC002855 AAH02855 BC008053 AAH08053 BM827551 BU616029 BX537895 CAD97886 CA842195 CB123593 DQ893174 ABM84100 DQ896473 ABM87472 XM_005271037 XP_005271094 XM_005271039 XP_005271096 XM_005271040 XP_005271097 XM_006710771 XP_006710834 XM_011541784 XP_011540086 XM_011541785 XP_011540087 NM_001034023 NP_001029195 NM_001034024 NP_001029196 NM_019100 NP_061973
|
| Function |
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may a
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.
|
