DMAP1

Gene Symbol	DMAP1
Entrez Gene	55929
Alt Symbol	DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4
Species	Human
Gene Type	protein-coding
Description	DNA methyltransferase 1 associated protein 1
Other Description	DNA methyltransferase 1-associated protein 1\|DNMT1 associated protein 1\|DNMT1-associated protein 1
Swissprots	Q0JSM4 Q9NPF5 Q9H0S8 A8K001 Q5TG41 Q7Z3H7 Q9P2C2 D3DPY8
Accessions	EAX07046 EAX07047 EAX07048 EAX07049 EAX07050 EAX07051 Q9NPF5 AB037846 BAA92663 AF265228 AAF87079 AK021605 BAB13854 AK054954 AK092898 AK096252 AK289366 BAF82055 AK293598 BAG57063 AK298793 BAG60930 AK300217 BAG61985 AK300372 BAG62108 AK300442 BAG62165 AL136657 CAB66592 AL137200 CAB69910 AM393614 CAL38490 BC002855 AAH02855 BC008053 AAH08053 BM827551 BU616029 BX537895 CAD97886 CA842195 CB123593 DQ893174 ABM84100 DQ896473 ABM87472 XM_005271037 XP_005271094 XM_005271039 XP_005271096 XM_005271040 XP_005271097 XM_006710771 XP_006710834 XM_011541784 XP_011540086 XM_011541785 XP_011540087 NM_001034023 NP_001029195 NM_001034024 NP_001029196 NM_019100 NP_061973
Function	Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may a
Subcellular Location	Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.

DMAP1 Antibody - 13326 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from various cell lines using DMAP1 Antibody.

Dmap1 (B-10) - sc-373949 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Dmap1 (B-10): sc-373949. Western blot analysis of Dmap1 expression in BJAB (A) and IMR-32 (B) nuclear extracts.

Dmap1 (H-300) - sc-135244 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Dmap1 (N-18) - sc-47583 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Dmap1 (N-18): sc-47583. Western blot analysis of Dmap1 expression in BJAB (A), NIH/3T3 (B), SW480 (C), IMR-32 (D) and Ramos (E) nuclear extracts.

Dmap1 (K-18) - sc-47582 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-DMAP1 antibody - ab3737 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Goat
Clonality	Polyclonal

Anti-DMAP1 antibody - ab49219 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 antibody (ab49219) at 1.25 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DMAP1 antibody - ab59739 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 antibody - ab68351 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

All lanes : Anti-DMAP1 antibody (ab68351) at 1/500 dilutionLane 1 : DMAP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg/ml per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-DMAP1 antibody - ab3736 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Goat
Clonality	Polyclonal

Anti-DMAP1 antibody - ab72072 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Lanes 1 - 2 : Anti-DMAP1 antibody (ab72072) at 4 µg/mlLanes 3 - 4 : Anti-DMAP1 antibody (ab72072) at 1 µg/mlLane 1 : human brain lysateLane 2 : human brain lysate plus immunizing peptideLane 3 : mouse brain lysateLane 4 : rat brain lysate

Anti-DMAP1 antibody [2277C2a] - ab50769 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2277C2a

Anti-DMAP1 antibody [2277C2a] (ab50769) + Recombinant DMAP1 (Immunizing protein)

Anti-DMAP1 antibody [EPR18179] - ab188407 from Abcam

Prices	$347.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR18179

All lanes : Anti-DMAP1 antibody [EPR18179] (ab188407) at 1/1000 dilutionLane 1 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysateLane 2 : Jurkat (Human T cell leukemia cells from peripheral blood) whole cell lysateLane 3 : 293 (Human epithelial cells from embryonic kidney) whole cell lysateLane 4 : MCF7 (Human breast adenocarcinoma cell line) whole cell lysateLane 5 : Ramos (Human Burkitt's lymphoma cell line) whole cell lysateLane 6 : Neuro-2a (Mouse neuroblastoma cells) whole cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-DMAP1 antibody - Carboxyterminal end - ab71789 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 antibody - Carboxyterminal end (ab71789) at 1/100 dilution + HL60 cell lysate at 12.5 µg

Anti-DMAP1 antibody - ChIP Grade - ab2848 from Abcam

Prices	$380.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of DMAP1 showing staining in the cytoplasm and nucleus of paraffin-treated human esophageal carcinoma tissue (right) compared with a negative control in the absence of primary antibody (left). Antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then incubated with ab2848 diluted by 3% BSA-PBS at a dilution of 1:100 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.

Anti-DMAP1 Antibody (aa441-456) - LS-C3013 from LifeSpan Bioscience

Prices	$285.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 Antibody - LS-C47459 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 Antibody - LS-C64921 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-DMAP1 Antibody - LS-C48652 from LifeSpan Bioscience

Prices	$410.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 Antibody - LS-C64923 from LifeSpan Bioscience

Prices	$575.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-DMAP1 Antibody - LS-C64922 from LifeSpan Bioscience

Prices	$575.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-DMAP1 Antibody (N-Terminus) - LS-C31117 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 Antibody (C-Terminus) - LS-C121178 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DMAP1 Antibody (clone 2277C2a) - LS-C184430 from LifeSpan Bioscience

Prices	$335.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2277C2a

Anti-DMAP1 Antibody (C-Terminus) - LS-C31116 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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