| Gene Symbol |
IL1B
|
| Entrez Gene |
102119749
|
| Alt Symbol |
-
|
| Species |
Monkey
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1, beta
|
| Other Description |
IL-1 beta|Interleukin-1 beta|interleukin-1 beta
|
| Swissprots |
P79182
|
| Accessions |
P79182 D63353 BAA09677 XM_005575284 XP_005575341 XM_005575285 XP_005575342
|
| Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
|
| Top Pathways |
Inflammatory bowel disease (IBD), Inflammatory mediator regulation of TRP channels, Cytokine-cytokine receptor interaction, Amoebiasis, Apoptosis
|
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