| Gene Symbol | IL1B |
|---|---|
| Entrez Gene | 102119749 |
| Alt Symbol | - |
| Species | Monkey |
| Gene Type | protein-coding |
| Description | interleukin 1, beta |
| Other Description | IL-1 beta|Interleukin-1 beta|interleukin-1 beta |
| Swissprots | P79182 |
| Accessions | P79182 D63353 BAA09677 XM_005575284 XP_005575341 XM_005575285 XP_005575342 |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Top Pathways | Inflammatory bowel disease (IBD), Inflammatory mediator regulation of TRP channels, Cytokine-cytokine receptor interaction, Amoebiasis, Apoptosis |