| Gene Symbol | IMPA1 |
|---|---|
| Entrez Gene | 3612 |
| Alt Symbol | IMP, IMPA |
| Species | Human |
| Gene Type | protein-coding |
| Description | inositol(myo)-1(or 4)-monophosphatase 1 |
| Other Description | D-galactose 1-phosphate phosphatase|IMP 1|IMPase 1|inositol monophosphatase 1|inositol-1(or 4)-monophosphatase 1|lithium-sensitive myo-inositol monophosphatase A1 |
| Swissprots | Q9UK71 P29218 J3KQT7 B7Z6Q4 B2R733 B4DLN3 |
| Accessions | AAD52997 CAA72195 EAW87095 EAW87096 EAW87097 EAW87098 EAW87099 EAW87100 P29218 AF042729 AAB97468 AI921211 AK297078 BAG59595 AK300750 BAH13340 AK312823 BAG35680 BC008381 AAH08381 BC009565 AAH09565 BP270804 DB299262 DC375686 HQ447127 ADQ31614 X66922 CAA47359 NM_001144878 NP_001138350 NM_001144879 NP_001138351 NM_005536 NP_005527 |
| Function | Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo- inositol monophosphates, myo-inositol 1,3-diphosphate, myo- inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17068342}. |
| Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |