Gene Symbol | IMPA1 |
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Entrez Gene | 3612 |
Alt Symbol | IMP, IMPA |
Species | Human |
Gene Type | protein-coding |
Description | inositol(myo)-1(or 4)-monophosphatase 1 |
Other Description | D-galactose 1-phosphate phosphatase|IMP 1|IMPase 1|inositol monophosphatase 1|inositol-1(or 4)-monophosphatase 1|lithium-sensitive myo-inositol monophosphatase A1 |
Swissprots | Q9UK71 P29218 J3KQT7 B7Z6Q4 B2R733 B4DLN3 |
Accessions | AAD52997 CAA72195 EAW87095 EAW87096 EAW87097 EAW87098 EAW87099 EAW87100 P29218 AF042729 AAB97468 AI921211 AK297078 BAG59595 AK300750 BAH13340 AK312823 BAG35680 BC008381 AAH08381 BC009565 AAH09565 BP270804 DB299262 DC375686 HQ447127 ADQ31614 X66922 CAA47359 NM_001144878 NP_001138350 NM_001144879 NP_001138351 NM_005536 NP_005527 |
Function | Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo- inositol monophosphates, myo-inositol 1,3-diphosphate, myo- inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17068342}. |
Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
Human IMPA1 full length protein - ab99519 from Abcam
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Human IMPA1 peptide - ab74969 from Abcam
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IMPA1 / IMP Antibody Blocking Peptide - LS-E21485 from LifeSpan Bioscience
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IMPA1 Recombinant Protein - H00003612-P01 from Novus Biologicals
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Recombinant Human IMPA1 Protein - NBP1-49304 from Novus Biologicals
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IMPA1 Protein (OPPA02563) - OPPA02563 from Aviva Systems Biology
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Human IMP1 protein - orb49447 from Biorbyt
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IMPA1 Blocking Peptide - 33R-4209 from Fitzgerald
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IMPA1 protein (His tag) - 80R-1499 from Fitzgerald
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Inositol monophosphatase / IMPA1 (1-277, His-tag) - AR09675PU-L from Acris Antibodies
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Inositol monophosphatase / IMPA1 (1-277, His-tag) - AR09675PU-N from Acris Antibodies
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Inositol monophosphatase / IMPA1 - H00003612-P01-10 from Acris Antibodies
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Inositol monophosphatase / IMPA1 - H00003612-P01-25 from Acris Antibodies
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Inositol Monophosphatase 1, Human Recombinant - 228-12162-1 from RayBiotech
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Recombinant Human Inositol Monophosphatase 1 - 228-12162-2 from RayBiotech
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Recombinant Human Inositol Monophosphatase 1 - 228-12162-3 from RayBiotech
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IMPA1, 1-277aa, Human, His tag, E.coli - 01-IMPA-1 from ARP American Research Products
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Inositol Monophosphatase 1, IMPA1, Human, Recombinant - 19-C234 from ARP American Research Products
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IMPA1 fusion protein - Ag9632 from Proteintech Group
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IMPA1 Human - ENPS-013 from NeoScientific
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Recombinant Human IMPA1 Enzyme - BP000771-C234 from Syd Labs
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Recombinant Human IMPA1 Enzyme - BP000771-ENZ-006 from Syd Labs
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IMPA1 Human Protein - GWB-BSP216 from Genway Biotech
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IMPA1, 1-277aa, Recombinant Protein - GWB-P1301A from Genway Biotech
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Recombinant Human IMPA1, His-tagged - IMPA1-2824H from Creative Biomart
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