| Gene Symbol |
SLC24A1
|
| Entrez Gene |
9187
|
| Alt Symbol |
CSNB1D, HsT17412, NCKX, NCKX1, RODX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
|
| Other Description |
Na(+)/K(+)/Ca(2+)-exchange protein 1|retinal rod Na+/Ca+/K+ exchanger|sodium/potassium/calcium exchanger 1|solute carrier family 24 member 1
|
| Swissprots |
O75184 Q17RM9 O43485 O60721
|
| Accessions |
EAW77739 EAW77740 EAW77741 O60721 AB014602 BAA31677 AF026132 AAB97832 AF062921 AAC16732 AF062922 AAC77912 AI026072 AK300633 BAG62323 AK304006 BAG64922 BC012630 BC029407 BC117263 AAI17264 BC143375 AAI43376 BM129630 BM681488 EL947516 EL948740 XM_005254778 XP_005254835 XM_005254781 XP_005254838 XM_006720764 XP_006720827 XM_006720767 XP_006720830 XM_006720768 XP_006720831 XM_006720769 XP_006720832 XM_011522219 XP_011520521 XM_011522220 XP_011520522 XM_011522221 XP_011520523 XM_011522222 XP_011520524 XM_011522223 XP_011520525 XM_011522225 XP_011520527 XM_011522226 XP_011520528 NM_001254740 NP_001241669 NM_001301031 NP_001287960 NM_001301032 NP_001287961 NM_001301033 NP_001287962 NM_004727 NP_004718
|
| Function |
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). {ECO:0000269|PubMed:10608890}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer. {ECO:0000269|PubMed:20850105}.
|
| Top Pathways |
Phototransduction
|