Gene Symbol | USB1 |
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Entrez Gene | 79650 |
Alt Symbol | C16orf57, HVSL1, Mpn1, PN, hUsb1 |
Species | Human |
Gene Type | protein-coding |
Description | U6 snRNA biogenesis 1 |
Other Description | HVSL motif containing 1|U six biogenesis 1|U6 snRNA phosphodiesterase|UPF0406 protein C16orf57|mutated in poikiloderma with neutropenia protein 1|putative U6 snRNA phosphodiesterase |
Swissprots | B4DZW5 B4DWE3 Q96FZ9 Q9H8X8 Q9BQ65 |
Accessions | EAW82962 EAW82963 EAW82964 Q9BQ65 AK023216 BAB14469 AK124443 AK126223 AK293220 BAG56759 AK298473 BAG60684 AK301494 BAG63005 AK303121 BAG64227 BC004415 AAH04415 BC006291 AAH06291 BC007774 AAH07774 BC010099 AAH10099 BC021554 AAH21554 BF733890 BI910866 BM193105 BQ223186 BX117268 DB364698 DB382938 DC363309 DC380401 JF432668 ADZ15885 XM_005256144 XP_005256201 XM_011523328 XP_011521630 XM_011523329 XP_011521631 XM_011523330 XP_011521632 XR_933427 XR_933428 NM_001195302 NP_001182231 NM_001204911 NP_001191840 NM_024598 NP_078874 |
Function | Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. {ECO:0000255|HAMAP- Rule:MF_03040, ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23190533}. |
Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03040, ECO:0000269|PubMed:22899009}. |
C16orf57 CRISPR/Cas9 KO Plasmid (h) - sc-413199 from Santa Cruz Biotechnology
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C16orf57 HDR Plasmid (h) - sc-413199-HDR from Santa Cruz Biotechnology
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C16orf57 Double Nickase Plasmid (h) - sc-413199-NIC from Santa Cruz Biotechnology
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C16orf57 Double Nickase Plasmid (h2) - sc-413199-NIC-2 from Santa Cruz Biotechnology
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C16orf57 CRISPR Activation Plasmid (h) - sc-413199-ACT from Santa Cruz Biotechnology
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C16orf57 CRISPR Activation Plasmid (h2) - sc-413199-ACT-2 from Santa Cruz Biotechnology
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C16orf57 Lentiviral Activation Particles (h) - sc-413199-LAC from Santa Cruz Biotechnology
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C16orf57 Lentiviral Activation Particles (h2) - sc-413199-LAC-2 from Santa Cruz Biotechnology
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C16orf57 siRNA (h) - sc-93471 from Santa Cruz Biotechnology
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C16orf57 shRNA Plasmid (h) - sc-93471-SH from Santa Cruz Biotechnology
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C16orf57 shRNA (h) Lentiviral Particles - sc-93471-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4413 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4413 from Sigma-Aldrich
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USB1 siRNA (Human) - CRJ2457 from Cohesion Biosciences
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USB1 - MBS8238011 from MyBioSource
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Human USB1 siRNA - orb272958 from Biorbyt
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USB1 shRNA Plasmid (Human) - CHJ2457 from Cohesion Biosciences
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USB1 miRNA 3'UTR clone - MiUTR3H-12808 from Creative biogene
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