Gene Symbol | FDPS |
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Entrez Gene | 2224 |
Alt Symbol | FPPS, FPS |
Species | Human |
Gene Type | protein-coding |
Description | farnesyl diphosphate synthase |
Other Description | (2E,6E)-farnesyl diphosphate synthase|FPP synthase|FPP synthetase|dimethylallyltranstransferase|farnesyl pyrophosphate synthase|farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase|geranyltranstransferase |
Swissprots | D3DV91 P14324 Q96G29 E9PCI9 |
Accessions | CCQ43162 EAW53075 EAW53076 EAW53077 EAW53078 P14324 AK021828 AK022841 BAG51125 AK291084 BAF83773 BC010004 AAH10004 BE047993 BP370037 CD675633 CN346026 D14697 BAA03523 DA610405 DQ893471 ABM84397 DQ895943 ABM86869 J05262 AAA52423 M29863 AAA35820 XM_005244962 XP_005245019 XM_005244963 XP_005245020 NM_001135821 NP_001129293 NM_001135822 NP_001129294 NM_001242824 NP_001229753 NM_001242825 NP_001229754 NM_002004 NP_001995 |
Function | Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
Subcellular Location | Cytoplasm. |
Top Pathways | Terpenoid backbone biosynthesis, HTLV-I infection, Influenza A |
FDPS CRISPR/Cas9 KO Plasmid (h) - sc-410781 from Santa Cruz Biotechnology
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FDPS HDR Plasmid (h) - sc-410781-HDR from Santa Cruz Biotechnology
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FDPS Double Nickase Plasmid (h) - sc-410781-NIC from Santa Cruz Biotechnology
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FDPS Double Nickase Plasmid (h2) - sc-410781-NIC-2 from Santa Cruz Biotechnology
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FDPS CRISPR Activation Plasmid (h) - sc-410781-ACT from Santa Cruz Biotechnology
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FDPS CRISPR Activation Plasmid (h2) - sc-410781-ACT-2 from Santa Cruz Biotechnology
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FDPS Lentiviral Activation Particles (h) - sc-410781-LAC from Santa Cruz Biotechnology
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FDPS Lentiviral Activation Particles (h2) - sc-410781-LAC-2 from Santa Cruz Biotechnology
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FDPS siRNA (h) - sc-75011 from Santa Cruz Biotechnology
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FDPS shRNA Plasmid (h) - sc-75011-SH from Santa Cruz Biotechnology
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FDPS shRNA (h) Lentiviral Particles - sc-75011-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU116031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8610 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8610 from Sigma-Aldrich
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FDPS siRNA (Human) - CRH1555 from Cohesion Biosciences
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FDPS - MBS8238912 from MyBioSource
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FDPS shRNA Plasmid (Human) - CHH1555 from Cohesion Biosciences
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FDPS miRNA 3'UTR clone - MiUTR3H-00775 from Creative biogene
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FDPS miRNA 3'UTR clone - MiUTR3H-00776 from Creative biogene
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FDPS miRNA 3'UTR clone - MiUTR3H-00777 from Creative biogene
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