Gene Symbol | KPTN |
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Entrez Gene | 11133 |
Alt Symbol | 2E4, MRT41 |
Species | Human |
Gene Type | protein-coding |
Description | kaptin (actin binding protein) |
Other Description | actin-associated protein 2E4|kaptin |
Swissprots | B3KN86 B4DQ76 Q96GT1 Q9Y664 |
Accessions | AAF98790 EAW57487 Q9Y664 AF105369 AAD39358 AK023996 BAG51248 AK225419 AK298672 BAG60838 BC009249 AAH09249 BG388698 DA129265 DA824599 DR759729 XM_011526398 XP_011524700 XM_011526399 XP_011524701 XM_011526400 XP_011524702 XM_011526401 XP_011524703 NM_001291296 NP_001278225 NM_007059 NP_008990 NR_111923 |
Function | Necessary for normal neuromorphogenesis. May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation. {ECO:0000269|PubMed:10099934, ECO:0000269|PubMed:1372044, ECO:0000269|PubMed:24239382}. |
Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Cell projection, stereocilium. Cell projection, growth cone. Note=Perinuclear at the tips of stereocilium in the inner ear. Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones. |
Kaptin CRISPR/Cas9 KO Plasmid (h) - sc-411571 from Santa Cruz Biotechnology
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Kaptin HDR Plasmid (h) - sc-411571-HDR from Santa Cruz Biotechnology
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Kaptin Double Nickase Plasmid (h) - sc-411571-NIC from Santa Cruz Biotechnology
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Kaptin Double Nickase Plasmid (h2) - sc-411571-NIC-2 from Santa Cruz Biotechnology
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Kaptin CRISPR Activation Plasmid (h) - sc-411571-ACT from Santa Cruz Biotechnology
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Kaptin CRISPR Activation Plasmid (h2) - sc-411571-ACT-2 from Santa Cruz Biotechnology
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Kaptin Lentiviral Activation Particles (h) - sc-411571-LAC from Santa Cruz Biotechnology
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Kaptin Lentiviral Activation Particles (h2) - sc-411571-LAC-2 from Santa Cruz Biotechnology
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Kaptin siRNA (h) - sc-60876 from Santa Cruz Biotechnology
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Kaptin shRNA Plasmid (h) - sc-60876-SH from Santa Cruz Biotechnology
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Kaptin shRNA (h) Lentiviral Particles - sc-60876-V from Santa Cruz Biotechnology
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Kaptin RNAi - H00011133-R01 from Novus Biologicals
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MISSION® esiRNA - EHU123021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11346 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11346 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01928 from Sigma-Aldrich
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KPTN siRNA (Human) - CRH7617 from Cohesion Biosciences
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shRNA set against Human KPTN(NM_007059.2) - SHL204606 from Creative biogene
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Human KPTN siRNA - orb268119 from Biorbyt
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KPTN shRNA Plasmid (Human) - CHH7617 from Cohesion Biosciences
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KPTN miRNA 3'UTR clone - MiUTR1H-05429 from Creative biogene
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