CDK7

Gene Symbol	CDK7
Entrez Gene	1022
Alt Symbol	CAK1, CDKN7, HCAK, MO15, STK1, p39MO15
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 7
Other Description	39 KDa protein kinase|CAK|CDK-activating kinase 1|TFIIH basal transcription factor complex kinase subunit|cell division protein kinase 7|cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)|homolog of Xenopus MO15 Cdk-activating kinase|kinase subunit of CAK|p39 Mo15|protein kinase|serine/threonine kinase stk1|serine/threonine protein kinase 1|serine/threonine protein kinase MO15|serine/threonine-protein kinase 1
Swissprots	Q9UE19 Q9BS60 P50613
Accessions	AAM77799 EAW51300 EAW51301 P50613 AK026509 AK308493 AM392563 CAL37441 AM392604 CAL37482 AM392628 CAL37506 AM393110 CAL37988 BC000834 AAH00834 BC005298 AAH05298 BI520184 CA437275 L20320 AAA36657 X76171 CAA53766 X77303 CAA54508 X77743 CAA54793 X79193 CAA55785 Y13120 CAA73587 XM_005248398 XP_005248455 XM_005276756 XP_005276813 XM_011543093 XP_011541395 XM_011543094 XP_011541396 XM_011546944 XP_011545246 NM_001799 NP_001790
Function	Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subuni
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
Tissue Specificity	Ubiquitous.
Top Pathways	Cell cycle, Nucleotide excision repair, Basal transcription factors

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDK7 + Cyclin H + MNAT1 full length protein - ab64303 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Cdk7 full length protein - ab126920 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human Cdk7 full length protein - ab158087 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Cdk7 protein fragment - ab158088 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CDK7 Antibody Blocking Peptide - LS-E10490 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK7 Antibody Blocking Peptide - LS-E10953 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK7 Antibody Blocking Peptide - LS-E7263 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cdk7 Protein - H00001022-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cdk7 Protein - H00001022-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Cdk7 Peptide - P1299 from Novus Biologicals Category Peptide Species Human

Mouse-Cdk7-Antibody-N-term-Blocking-Peptide - BP14782a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Mouse

Phospho-CDK7T170-Antibody-Blocking-peptide - BP3068a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-Cdk7-T170-Antibody-Blocking-Peptide - BP3696a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Biotinylated-Cdk7-T170-Non-phospho-Control-Peptide - SP2038d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

Cdk7-T170-Non-phospho-Control-Peptide - SP2038c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Cdk7-T170-Phospho-Peptide - SP2038a from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

CDK7 Protein - GTX111919-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

AMPK gamma 3 blocking peptide - GTX88592-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

Human CAK1 protein - orb139354 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human CDK7 protein - orb180240 from Biorbyt Category Protein Prices $383.00, $553.00, $1,751.00, $2,474.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

Human CAK1 protein - orb139355 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human CAK1 protein - orb139356 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

CDK7 peptide - orb72511 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

CDK7 Blocking Peptide - 33R-6860 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKACB protein (His tag) - 80R-3799 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

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