CDK7

Gene Symbol	CDK7
Entrez Gene	1022
Alt Symbol	CAK1, CDKN7, HCAK, MO15, STK1, p39MO15
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 7
Other Description	39 KDa protein kinase|CAK|CDK-activating kinase 1|TFIIH basal transcription factor complex kinase subunit|cell division protein kinase 7|cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)|homolog of Xenopus MO15 Cdk-activating kinase|kinase subunit of CAK|p39 Mo15|protein kinase|serine/threonine kinase stk1|serine/threonine protein kinase 1|serine/threonine protein kinase MO15|serine/threonine-protein kinase 1
Swissprots	Q9UE19 Q9BS60 P50613
Accessions	AAM77799 EAW51300 EAW51301 P50613 AK026509 AK308493 AM392563 CAL37441 AM392604 CAL37482 AM392628 CAL37506 AM393110 CAL37988 BC000834 AAH00834 BC005298 AAH05298 BI520184 CA437275 L20320 AAA36657 X76171 CAA53766 X77303 CAA54508 X77743 CAA54793 X79193 CAA55785 Y13120 CAA73587 XM_005248398 XP_005248455 XM_005276756 XP_005276813 XM_011543093 XP_011541395 XM_011543094 XP_011541396 XM_011546944 XP_011545246 NM_001799 NP_001790
Function	Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subuni
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
Tissue Specificity	Ubiquitous.
Top Pathways	Cell cycle, Nucleotide excision repair, Basal transcription factors

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human Phospho-CDK7 (Thr170) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1336 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human CDK7 ELISA Kit (Cell-Based ELISA) - LS-F1880 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Rabbit anti-CDK7 Antibody, Affinity Purified - PLA0103 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human Cyclin-Dependent Kinase 7 ELISA Kit - abx053448 from Abbexa Category ELISA Kit

Cyclin Dependent Kinase 7, CDK7, Human, ELISA Kit - E-EL-H2325 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100mU/mL

Cyclin-dependent kinase 7, CDK7, Human, ELISA Kit - E1880h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Epithelial discoidin domain-containing receptor 1 (DDR1), Human, ELISA Kit - CSB-EL006595HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

FMS Like Tyrosine Kinase 3 (Flt3), Human, ELISA Kit - SEA039Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.108ng/mL Range 0.312-20ng/mL

Mesothelin (MSLN_ELISA KIT, Human, ELISA Kit - CSB-E13382h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.04 ng/ml Range 0.156 ng/ml-10 ng/ml

Cyclin Dependent Kinase 7, CDK7, Rabbit, ELISA Kit - E-EL-RB0473 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 7, CDK7, Chicken, ELISA Kit - E-EL-Ch0259 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Cyclin Dependent Kinase 7, CDK7, Porcine, ELISA Kit - E-EL-P0530 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 7, CDK7, Sheep, ELISA Kit - E-EL-S0889 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Cyclin Dependent Kinase 7, CDK7, Guinea Pig, ELISA Kit - E-EL-GP1287 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin Dependent Kinase 7, CDK7, Monkey, ELISA Kit - E-EL-MK1842 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CDK-7 ELISA Kit - HC0732 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CDK-7 ELISA Kit - AC0732 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

CDK7, ELISA Kit - MBS2504448 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938mU/mL Range 1.563--100mU/mL

CDK7, ELISA Kit - MBS2513976 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

CDK7, ELISA Kit - MBS2506301 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CDK7, ELISA Kit - MBS2511172 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

CDK7, ELISA Kit - MBS2508901 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

CDK7, ELISA Kit - MBS2510450 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

CDK7, ELISA Kit - MBS2511773 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CDK7 Colorimetric Cell-Based ELISA Kit - CB5132 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

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