| Gene Symbol |
RNF38
|
| Entrez Gene |
152006
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 38
|
| Other Description |
E3 ubiquitin-protein ligase RNF38
|
| Swissprots |
B3KSG4 Q9H0F5 B1AM81 Q9H748 Q7LB33 Q8N0Y0 B1AM82 E7EVL3 A6PVP9
|
| Accessions |
EAW58305 Q9H0F5 AF394047 AAM73697 AK024996 BAB15050 AK025466 AK093480 BAG52726 AK097653 AL120640 AL136817 CAB66751 AM392682 CAL37560 AV690059 AX748155 BC033786 AAH33786 BG722531 BI459742 BI520161 BU731024 DA189510 DA483270 DQ895235 ABM86161 EU176239 ABW03690 XM_005251366 XP_005251423 XM_005251367 XP_005251424 XM_005251368 XP_005251425 XM_006716721 XP_006716784 XM_011517712 XP_011516014 XM_011517713 XP_011516015 NM_022781 NP_073618 NM_194328 NP_919309 NM_194329 NP_919310 NM_194330 NP_919311 NM_194332 NP_919313 NM_194331
|
| Function |
Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. {ECO:0000269|PubMed:23973461}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23973461}.
|
| Tissue Specificity |
Widely expressed with highest levels in testis. {ECO:0000269|PubMed:12074600}.
|
![Western Blot: RNF38 Overexpression Lysate (Adult Normal) [NBP2-06407] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF38.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/17082_RNF38%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-06407-img0001.jpg)