| Gene Symbol |
DNMT1
|
| Entrez Gene |
281119
|
| Alt Symbol |
DNMT
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
DNA (cytosine-5-)-methyltransferase 1
|
| Other Description |
DNA (cytosine 5 ) methyltransferase 1|DNA (cytosine-5)-methyltransferase 1|DNA methyltransferase (cytosine 5 ) methyltransferase|DNA methyltransferase b
|
| Swissprots |
Q24K09 Q6Y856 Q7YS60
|
| Accessions |
DAA27999 Q24K09 AY173048 AAO44952 AY244709 AAP20551 AY486458 AAR27835 BC114063 AAI14064 DV890836 EH376402 EU273277 ACA28713 XM_005208712 XP_005208769 XM_010806776 XP_010805078 NM_182651 NP_872592
|
| Function |
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Cysteine and methionine metabolism, MicroRNAs in cancer
|