DNMT1

Gene Symbol DNMT1
Entrez Gene 281119
Alt Symbol DNMT
Species Bovine
Gene Type protein-coding
Description DNA (cytosine-5-)-methyltransferase 1
Other Description DNA (cytosine 5 ) methyltransferase 1|DNA (cytosine-5)-methyltransferase 1|DNA methyltransferase (cytosine 5 ) methyltransferase|DNA methyltransferase b
Swissprots Q24K09 Q6Y856 Q7YS60
Accessions DAA27999 Q24K09 AY173048 AAO44952 AY244709 AAP20551 AY486458 AAR27835 BC114063 AAI14064 DV890836 EH376402 EU273277 ACA28713 XM_005208712 XP_005208769 XM_010806776 XP_010805078 NM_182651 NP_872592
Function Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9 (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}.
Top Pathways Cysteine and methionine metabolism, MicroRNAs in cancer

Anti-Dnmt1 antibody - ab109981 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-Dnmt1 antibody (ab109981) at 0.5 µg/ml + Jurkat cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-Dnmt1 antibody - ab4870 from Abcam

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab4870 used in Western blot to detect Dnmt1 in Jurkat cell lysate.

Anti-Dnmt1 antibody - ab77689 from Abcam

Prices $359.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
Anti-Dnmt1 antibody (ab77689) at 0.5 µg/ml + Jurkat cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-Dnmt1 antibody - ab11891 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Dnmt1 antibody [60B1220.1] (Biotin) - ab183404 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 60B1220.1

Anti-Dnmt1 antibody [60B1220.1] (FITC) - ab183402 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 60B1220.1

Anti-Dnmt1 antibody [60B1220.1] (HRP) - ab183403 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 60B1220.1

Anti-Dnmt1 antibody [60B1220.1] - ChIP Grade - ab13537 from Abcam

Prices $401.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 60B1220.1
ab13537 at 1/10000 dilution staining Dnmt1 in mouse brain tissue section by Immunohistochemistry (Bouin's fixative fixed paraffin-embedded tissue sections). Tissue underwent heat mediated antigen retrieval in microwave with two, 5 minutes incubation intervals in citrate buffer. An antibody amplifier™ was used for staining. A HRP-conjugated anti-mouse secondary was used at 1/10 dilution.

Anti-Dnmt1 antibody [60B1220.1] - ChIP Grade - ab92453 from Abcam

Prices $392.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 60B1220.1
All lanes : Anti-Dnmt1 antibody [60B1220.1] - ChIP Grade (ab92453)Lane 1 : 2102EP (human embryonic carcinoma) with absence of blocking peptideLane 2 : 2102EP (human embryonic carcinoma) with blocking peptideLane 3 : Recombinant human Dnmt1 protein with absence of blocking peptideLane 4 : Recombinant human Dnmt1 protein with blocking peptideLane 5 : NIH 3T3 (mouse embryonic fibroblast) with absence of blocking peptideLane 6 : NIH 3T3 (mouse embryonic fibroblast) with blocking peptideLane 7 : D3 (mouse embryonic stem cell) with absence of blocking peptideLane 8 : D3 (mouse embryonic stem cell) with blocking peptideSecondaryGoat anti-Mouse IgG HRP-conjugated secondary antibody

Anti-Dnmt1 antibody - C-terminal - ab189189 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling Dnmt1 with ab189189 at 10 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Bovine DNA Antibody - GWB-539FA5 from Genway Biotech

Prices $347.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
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