Gene Symbol | MBOAT1 |
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Entrez Gene | 154141 |
Alt Symbol | 1, LPEAT1, LPLAT, LPLAT 1, LPSAT, OACT1, dJ434O11.1 |
Species | Human |
Gene Type | protein-coding |
Description | membrane bound O-acyltransferase domain containing 1 |
Other Description | 1-acylglycerophosphoserine O-acyltransferase|O-acyltransferase (membrane bound) domain containing 1|O-acyltransferase domain-containing protein 1|lyso-PS acyltransferase|lysophosphatidylethanolamine acyltransferase 1|lysophosphatidylserine acyltransferase|lysophospholipid acyltransferase 1|membrane-bound O-acyltransferase domain-containing protein 1 |
Swissprots | B4E3J4 Q8N9R5 Q6ZNC8 B4DL59 Q86XC2 A9EDQ5 |
Accessions | Q6ZNC8 AB305043 BAF93899 AK093994 BAC04264 AK131269 BAD18447 AK296857 BAG59421 AK304748 BAG65506 BC045695 BC150650 AAI50651 BC150652 AAI50653 BC156593 AAI56594 BM978819 XM_006714999 XP_006715062 XM_006715000 XP_006715063 XM_011514313 XP_011512615 XR_926070 XR_926071 NM_001080480 NP_001073949 NR_073465 |
Function | Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18772128}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in neutrophils. {ECO:0000269|PubMed:18772128}. |
Top Pathways | Glycerolipid metabolism, Glycerophospholipid metabolism |
MBOAT1 CRISPR/Cas9 KO Plasmid (h) - sc-406397 from Santa Cruz Biotechnology
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MBOAT1 HDR Plasmid (h) - sc-406397-HDR from Santa Cruz Biotechnology
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MBOAT1 Double Nickase Plasmid (h) - sc-406397-NIC from Santa Cruz Biotechnology
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MBOAT1 Double Nickase Plasmid (h2) - sc-406397-NIC-2 from Santa Cruz Biotechnology
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MBOAT1 CRISPR Activation Plasmid (h) - sc-406397-ACT from Santa Cruz Biotechnology
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MBOAT1 CRISPR Activation Plasmid (h2) - sc-406397-ACT-2 from Santa Cruz Biotechnology
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MBOAT1 Lentiviral Activation Particles (h) - sc-406397-LAC from Santa Cruz Biotechnology
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MBOAT1 Lentiviral Activation Particles (h2) - sc-406397-LAC-2 from Santa Cruz Biotechnology
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MBOAT1 siRNA (h) - sc-75757 from Santa Cruz Biotechnology
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MBOAT1 shRNA Plasmid (h) - sc-75757-SH from Santa Cruz Biotechnology
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MBOAT1 shRNA (h) Lentiviral Particles - sc-75757-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13089 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13089 from Sigma-Aldrich
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MBOAT1 siRNA (Human) - CRJ5789 from Cohesion Biosciences
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shRNA set against Human MBOAT1 (NM_001080480.1) - SHH338935 from Creative biogene
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shRNA set against Human MBOAT1(NM_001080480.1) - SHH179903 from Creative biogene
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Human MBOAT1 siRNA - orb276290 from Biorbyt
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MBOAT1 shRNA Plasmid (Human) - CHJ5789 from Cohesion Biosciences
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MBOAT1 miRNA 3'UTR clone - MiUTR1H-06139 from Creative biogene
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