DAB2IP
| Gene Symbol | DAB2IP |
|---|---|
| Entrez Gene | 153090 |
| Alt Symbol | AF9Q34, AIP-1, AIP1, DIP1/2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DAB2 interacting protein |
| Other Description | ASK-interacting protein 1|ASK1-interacting protein 1|DAB2 interaction protein|DOC-2/DAB2 interactive protein|disabled homolog 2-interacting protein|nGAP-like protein |
| Swissprots | Q9C0C0 Q96SE1 Q5VWQ8 B0QZB1 G3XA90 A6H8V2 A6NHI9 Q8TDL2 |
| Accessions | EAW87501 EAW87502 EAW87503 EAW87504 Q5VWQ8 AB051530 BAB21834 AF367051 AAM00371 AK054851 AK096378 AK096391 AK124609 AK124610 BAG54058 AY032952 AAK50336 BC011496 BC037314 BC040911 BC146762 AAI46763 BM545676 BM546615 DA373245 XM_005251719 XP_005251776 XM_005251721 XP_005251778 XM_005251724 XP_005251781 XM_011518264 XP_011516566 XM_011518265 XP_011516567 XM_011518266 XP_011516568 XM_011518267 XP_011516569 XM_011518268 XP_011516570 XM_011518269 XP_011516571 XM_011518270 XP_011516572 XM_011518271 XP_011516573 NM_032552 NP_115941 NM_138709 NP_619723 |
| Function | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathw |
| Subcellular Location | Cytoplasm. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane. Cell projection, dendrite {ECO:0000250}. Note=Localized in soma and dendrites of Purkinje cells as well as in scattered cell bodies in the molecular layer of the cerebellum (By similarity). Colocalizes with TIRAP at the plasma membrane. Colocalizes with ARF6 at the plasma membrane and endocytic vesicles. Translocates from the plasma membrane to the cytoplasm in response to TNF-alpha. Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for plasma membrane localization. {ECO:0000250}. |
| Tissue Specificity | Expressed in endothelial and vascular smooth muscle cells (VSMCs). Expressed in prostate epithelial but poorly in prostate cancer cells. Poorly expressed in medulloblastoma cells compared to cerebellar precursor proliferating progenitor cells (at protein level). Low expression in prostate. Down- regulated in prostate cancer. {ECO:0000269|PubMed:11944990, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229}. |
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