DAB2IP

Gene Symbol	DAB2IP
Entrez Gene	153090
Alt Symbol	AF9Q34, AIP-1, AIP1, DIP1/2
Species	Human
Gene Type	protein-coding
Description	DAB2 interacting protein
Other Description	ASK-interacting protein 1|ASK1-interacting protein 1|DAB2 interaction protein|DOC-2/DAB2 interactive protein|disabled homolog 2-interacting protein|nGAP-like protein
Swissprots	Q9C0C0 Q96SE1 Q5VWQ8 B0QZB1 G3XA90 A6H8V2 A6NHI9 Q8TDL2
Accessions	EAW87501 EAW87502 EAW87503 EAW87504 Q5VWQ8 AB051530 BAB21834 AF367051 AAM00371 AK054851 AK096378 AK096391 AK124609 AK124610 BAG54058 AY032952 AAK50336 BC011496 BC037314 BC040911 BC146762 AAI46763 BM545676 BM546615 DA373245 XM_005251719 XP_005251776 XM_005251721 XP_005251778 XM_005251724 XP_005251781 XM_011518264 XP_011516566 XM_011518265 XP_011516567 XM_011518266 XP_011516568 XM_011518267 XP_011516569 XM_011518268 XP_011516570 XM_011518269 XP_011516571 XM_011518270 XP_011516572 XM_011518271 XP_011516573 NM_032552 NP_115941 NM_138709 NP_619723
Function	Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathw
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane. Cell projection, dendrite {ECO:0000250}. Note=Localized in soma and dendrites of Purkinje cells as well as in scattered cell bodies in the molecular layer of the cerebellum (By similarity). Colocalizes with TIRAP at the plasma membrane. Colocalizes with ARF6 at the plasma membrane and endocytic vesicles. Translocates from the plasma membrane to the cytoplasm in response to TNF-alpha. Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for plasma membrane localization. {ECO:0000250}.
Tissue Specificity	Expressed in endothelial and vascular smooth muscle cells (VSMCs). Expressed in prostate epithelial but poorly in prostate cancer cells. Poorly expressed in medulloblastoma cells compared to cerebellar precursor proliferating progenitor cells (at protein level). Low expression in prostate. Down- regulated in prostate cancer. {ECO:0000269|PubMed:11944990, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DAB2IP protein fragment - ab165657 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human DAB2IP Protein - H00153090-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ARMER Peptide - GTX85516-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

DAB2IP - H00153090-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DAB2IP - H00153090-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DAB2IP fusion protein - ag20308 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PDCD6IP Human - PRPS-799 from NeoScientific Category Protein Prices $65.00, $169.00, $2,925.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Alix 1-392aa - CMB-315 from Reagent Proteins Category Protein Prices $441.00, $805.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

PDCD6IP Human - NKX-163 from Reagent Proteins Category Protein Prices $348.00, $2,588.00 Sizes 25.00 µg, 1 mg Source E.coli Species Human

Recombinant Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) - RPB247Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Disabled homolog 2-interacting protein(DAB2IP) ,partial - CSB-YP730138HU CSB-EP730138HU CSB-BP730138HU CSB-MP730138HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DAB2IP (transcript variant 1) - TP314413 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Programmed Cell Death 6 Interacting Protein Human Recombinant - Pr21743 from ProMab Category Protein Prices $50.00, $130.00, $2,250.00 Sizes 5 μg, 25 μg, 1 mg Source Escherichia Coli. Species Human

DAB2IP Peptide, Human - M34GP04007H from Creative Peptides Category Peptide Source Synthetic. Species Human

Disabled homolog 2-interacting protein (DAB2IP), partial, Recombinant Protein - MBS1443080 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

AIP-1 peptide - orb256956 from Biorbyt Category Peptide

Recombinant Human DAB2IP Protein, GST-tagged - DAB2IP-2318H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human DAB2IP Protein, MYC/DDK-tagged - DAB2IP-988H from Creative Biomart Category Protein Source HEK293 Species Human

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