PLA2G6

Gene Symbol PLA2G6
Entrez Gene 8398
Alt Symbol CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta
Species Human
Gene Type protein-coding
Description phospholipase A2, group VI (cytosolic, calcium-independent)
Other Description 85 kDa calcium-independent phospholipase A2|85/88 kDa calcium-independent phospholipase A2|GVI PLA2|calcium-independent phospholipase A2|cytosolic, calcium-independent phospholipase A2|group VI phospholipase A2|iPLA2-beta|intracellular membrane-associated calcium-independent phospholipase A2 beta|neurodegeneration with brain iron accumulation 2|patatin-like phospholipase domain containing 9|patatin-like phospholipase domain-containing protein 9
Swissprots O60733 Q9UG29 O75645 A8K597 Q9UIT0 Q9Y671 B0QYE8 Q8N452
Accessions AAD30424 AAF34728 AAR92478 EAW60219 EAW60220 O60733 AF064594 AAC97486 AF102988 AAD41722 AF102989 AAD41723 AK001290 AK096521 BAG53314 AK128862 AK290825 BAF83514 AK291212 BAF83901 AK300459 BAH13289 AK308308 AL080187 CAB45768 BC034592 BC036742 AAH36742 BC051904 AAH51904 CR456543 CAG30429 CU013143 CAK54574 CU013431 CAK54873 XM_005261764 XP_005261821 XM_005261765 XP_005261822 XM_005261766 XP_005261823 XM_005261771 XP_005261828 XM_006724332 XP_006724395 XM_011530422 XP_011528724 XM_011530423 XP_011528725 XM_011530424 XP_011528726 XM_011530425 XP_011528727 XM_011530426 XP_011528728 XM_011530427 XP_011528729 XM_011530428 XP_011528730 XR_244390 XR_244392 XR_430411 XR_430412 XR_937937 XR_937938 XR_937939 XR_937940 NM_001004426 NP_001004426 NM_001199562 NP_001186491 NM_003560 NP_003551
Function Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.
Subcellular Location Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
Tissue Specificity Four different transcripts were found to be expressed in a distinct tissue distribution.
Top Pathways Fc gamma R-mediated phagocytosis, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels, Ether lipid metabolism, Glycerophospholipid metabolism

group VI iPLA 2 (A-10) - sc-137189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
group VI iPLA<sub>2</sub> (A-10): sc-137189. Western blot analysis of group VI iPLA<sub>2</sub> expression in non-transfected: sc-117752 (A) and human group VI iPLA<sub>2</sub> transfected: sc-116309 (B) 293T whole cell lysates.

group VI iPLA 2 (D-4) - sc-376563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
group VI iPLA<sub>2</sub> (D-4): sc-376563. Western blot analysis of group VI iPLA<sub>2</sub> expression in non-transfected: sc-117752 (A) and human group VI iPLA<sub>2</sub> transfected: sc-116309 (B) 293T whole cell lysates and rat testis tissue extract (C).

group VI iPLA 2 (D-20) - sc-14466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
group VI iPLA<sub>2</sub> (D-20): sc-14466. Western blot analysis of group VI iPLA<sub>2</sub> expression in rat testis extract.

group VI iPLA 2 (E-8) - sc-166616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
group VI iPLA<sub>2</sub> (E-8): sc-166616. Western blot analysis of group VI iPLA<sub>2</sub> expression in non-transfected: sc-117752 (A) and human group VI iPLA<sub>2</sub> transfected: sc-116309 (B) 293T whole cell lysates.

group VI iPLA 2 (H-120) - sc-25504 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
group VI iPLA<sub>2</sub> (H-120): sc-25504. Western blot analysis of group VI iPLA<sub>2</sub> expression in 293T whole cell lysate.

group VI iPLA 2 (P-19) - sc-14462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
group VI iPLA<sub>2</sub> (P-19): sc-14462. Immunofluorescence staining of methanol-fixed SK-N-MC cells showing membrane and cytoplasmic localization.

group VI iPLA 2 (T-14) - sc-14463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
group VI iPLA<sub>2</sub> (T-14): sc-14463. Western blot analysis of group VI iPLA<sub>2</sub> expression in non-transfected: sc-117752 (A) and human group VI iPLA<sub>2</sub> transfected: sc-116309 (B) 293T whole cell lysates.

Anti-Calcium-independent Phospholipase A2 antibody - ab126248 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Calcium-independent Phospholipase A2 antibody (ab126248) at 1/500 dilution + U87-MG whole cell lysate at 30 µg

Anti-Calcium-independent Phospholipase A2 antibody - ab104416 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Calcium-independent Phospholipase A2 antibody (ab104416) at 1 µg/ml + Human kidney tissue lysate at 50 µg

Anti-Calcium-independent Phospholipase A2 antibody - ab103258 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Calcium-independent Phospholipase A2 antibody (ab103258) at 1/50 dilution + HepG2 cell lysate at 35 µg

Anti-Calcium-independent Phospholipase A2 antibody - ab167297 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Calcium-independent Phospholipase A2 antibody (ab167297) at 1 µg/mlLane 1 : Calcium-independent Phospholipase A2 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG HRP at 1/2500 dilution

Anti-Calcium-independent Phospholipase A2 antibody - ab23706 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab23706 staining Calcium-independent Phospholipase A2 (red) in rat carotid artery segments by Immunohistochemistry (frozen sections). Rats were either untreated (left panel) or treated with hydralazine (right panel). Tissue was fixed with acetone and blocked with 2% BSA/PBS for 30 minutes at room temperature. Samples were incubated with primary antibody (1/400 in 0.1% BSA/PBS) overnight at 4°C. An AlexaFluor®546-conjugated anti-rabbit IgG was used as the secondary antibody. Nuclei were stained with DAPI (blue).

Anti-Calcium-independent Phospholipase A2 antibody [10A2] - ab180469 from Abcam

Prices $357.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10A2
All lanes : Anti-Calcium-independent Phospholipase A2 antibody [10A2] (ab180469) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Calcium-independent Phospholipase A2 cDNALysates/proteins at 5 µg per lane.

Anti-PLA2G6 / IPLA2 Antibody (aa481-702, Biotin) - LS-C298803 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2G6 / IPLA2 Antibody (aa481-702, Biotin) - LS-C298802 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2G6 / IPLA2 Antibody (aa481-702, FITC) - LS-C305185 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2G6 / IPLA2 Antibody (aa481-702, FITC) - LS-C305186 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2G6 / IPLA2 Antibody (aa481-702) - LS-C295911 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PLA2G6 / IPLA2.

Anti-PLA2G6 / IPLA2 Antibody (aa481-702) - LS-C295909 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PLA2G6 / IPLA2.

Anti-PLA2G6 / IPLA2 Antibody (aa490-752, clone 10A2) - LS-C340558 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10A2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PLA2G6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PLA2G6.

Anti-PLA2G6 / IPLA2 Antibody (aa490-752, clone 10G4) - LS-C338668 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10G4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PLA2G6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PLA2G6.

Anti-PLA2G6 / IPLA2 Antibody (aa681-691) - LS-C152740 from LifeSpan Bioscience

Prices $355.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
WB: RINB2 cell lysate was probed with anti-iPLA2 (1:500).

Anti-PLA2G6 / IPLA2 Antibody (aa484-701) - LS-C314497 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PLA2G6 / IPLA2.

Anti-PLA2G6 / IPLA2 Antibody (aa557-576) IHC-plus™ - LS-B1603 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-PLA2G6 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1603 dilution 1:200.

Anti-PLA2G6 / IPLA2 Antibody (aa551-580) - LS-C163764 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PLA2G6 Antibody IHC of formalin-fixed and paraffin-embedded testis carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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