PLA2G6

Gene Symbol PLA2G6
Entrez Gene 8398
Alt Symbol CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta
Species Human
Gene Type protein-coding
Description phospholipase A2, group VI (cytosolic, calcium-independent)
Other Description 85 kDa calcium-independent phospholipase A2|85/88 kDa calcium-independent phospholipase A2|GVI PLA2|calcium-independent phospholipase A2|cytosolic, calcium-independent phospholipase A2|group VI phospholipase A2|iPLA2-beta|intracellular membrane-associated calcium-independent phospholipase A2 beta|neurodegeneration with brain iron accumulation 2|patatin-like phospholipase domain containing 9|patatin-like phospholipase domain-containing protein 9
Swissprots O60733 Q9UG29 O75645 A8K597 Q9UIT0 Q9Y671 B0QYE8 Q8N452
Accessions AAD30424 AAF34728 AAR92478 EAW60219 EAW60220 O60733 AF064594 AAC97486 AF102988 AAD41722 AF102989 AAD41723 AK001290 AK096521 BAG53314 AK128862 AK290825 BAF83514 AK291212 BAF83901 AK300459 BAH13289 AK308308 AL080187 CAB45768 BC034592 BC036742 AAH36742 BC051904 AAH51904 CR456543 CAG30429 CU013143 CAK54574 CU013431 CAK54873 XM_005261764 XP_005261821 XM_005261765 XP_005261822 XM_005261766 XP_005261823 XM_005261771 XP_005261828 XM_006724332 XP_006724395 XM_011530422 XP_011528724 XM_011530423 XP_011528725 XM_011530424 XP_011528726 XM_011530425 XP_011528727 XM_011530426 XP_011528728 XM_011530427 XP_011528729 XM_011530428 XP_011528730 XR_244390 XR_244392 XR_430411 XR_430412 XR_937937 XR_937938 XR_937939 XR_937940 NM_001004426 NP_001004426 NM_001199562 NP_001186491 NM_003560 NP_003551
Function Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.
Subcellular Location Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
Tissue Specificity Four different transcripts were found to be expressed in a distinct tissue distribution.
Top Pathways Fc gamma R-mediated phagocytosis, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels, Ether lipid metabolism, Glycerophospholipid metabolism

group VI iPLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-402107 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 HDR Plasmid (h) - sc-402107-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 Double Nickase Plasmid (h) - sc-402107-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 Double Nickase Plasmid (h2) - sc-402107-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 CRISPR Activation Plasmid (h) - sc-402107-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 CRISPR Activation Plasmid (h2) - sc-402107-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 Lentiviral Activation Particles (h) - sc-402107-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 Lentiviral Activation Particles (h2) - sc-402107-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

group VI iPLA 2 siRNA (h) - sc-43819 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

group VI iPLA 2 shRNA Plasmid (h) - sc-43819-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

group VI iPLA 2 shRNA (h) Lentiviral Particles - sc-43819-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLA2G6 RNAi - H00008398-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU158861 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16901 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16901 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05736 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05736

PLA2G6 siRNA (Human) - CRH5503 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLA2G6 RNAi - H00008398-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PLA2G6 (NM_003560.2) - SHH376892 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLA2G6(NM_001004426.1) - SHR118572 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLA2G6(NM_003560.2) - SHR118626 from Creative biogene

Category siRNA
Species Reactivities Human

Human PLA2G6 siRNA - orb266005 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLA2G6 shRNA Plasmid (Human) - CHH5503 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLA2G6 miRNA 3'UTR clone - MiUTR1H-07964 from Creative biogene

Species Reactivities Human

PLA2G6 miRNA 3'UTR clone - MiUTR1H-07965 from Creative biogene

Species Reactivities Human
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