Gene Symbol | OTOP1 |
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Entrez Gene | 133060 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | otopetrin 1 |
Other Description | otopetrin-1 |
Swissprots | Q7RTM1 A1L476 |
Accessions | DAA00902 EAW82445 EAW82446 Q7RTM1 BC130430 AAI30431 BC130432 AAI30433 BK000653 DAA00901 NM_177998 NP_819056 |
Function | Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Multi-pass membrane protein. Secreted, extracellular space. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium. {ECO:0000250}. |
OTOP1 CRISPR/Cas9 KO Plasmid (h) - sc-414400 from Santa Cruz Biotechnology
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OTOP1 HDR Plasmid (h) - sc-414400-HDR from Santa Cruz Biotechnology
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OTOP1 Double Nickase Plasmid (h) - sc-414400-NIC from Santa Cruz Biotechnology
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OTOP1 Double Nickase Plasmid (h2) - sc-414400-NIC-2 from Santa Cruz Biotechnology
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OTOP1 CRISPR Activation Plasmid (h) - sc-414400-ACT from Santa Cruz Biotechnology
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OTOP1 CRISPR Activation Plasmid (h2) - sc-414400-ACT-2 from Santa Cruz Biotechnology
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OTOP1 Lentiviral Activation Particles (h) - sc-414400-LAC from Santa Cruz Biotechnology
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OTOP1 Lentiviral Activation Particles (h2) - sc-414400-LAC-2 from Santa Cruz Biotechnology
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OTOP1 siRNA (h) - sc-89314 from Santa Cruz Biotechnology
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OTOP1 shRNA Plasmid (h) - sc-89314-SH from Santa Cruz Biotechnology
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OTOP1 shRNA (h) Lentiviral Particles - sc-89314-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16188 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16188 from Sigma-Aldrich
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OTOP1 siRNA (Human) - CRJ5110 from Cohesion Biosciences
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shRNA set against Human OTOP1 (NM_177998.1) - SHH368996 from Creative biogene
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shRNA set against Human OTOP1(NM_177998.1) - SHR083270 from Creative biogene
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Human OTOP1 siRNA - orb275611 from Biorbyt
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OTOP1 shRNA Plasmid (Human) - CHJ5110 from Cohesion Biosciences
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OTOP1 miRNA 3'UTR clone - MiUTR1H-07411 from Creative biogene
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