CD22

Gene Symbol	CD22
Entrez Gene	933
Alt Symbol	SIGLEC-2, SIGLEC2
Species	Human
Gene Type	protein-coding
Description	CD22 molecule
Other Description	B-cell receptor CD22|B-lymphocyte cell adhesion molecule|BL-CAM|CD22 antigen|T-cell surface antigen Leu-14|sialic acid binding Ig-like lectin 2|sialic acid-binding Ig-like lectin 2
Swissprots	Q9UQA7 Q01665 Q32M46 F5GYU4 Q9Y2A6 O95699 P20273 Q9UQA6 O95702 O95703 F5H7U3 Q9UQB0 Q9UQA8 Q92872 Q92873 O95701 Q9UQA9
Accessions	AAB06448 AAB06449 AAC18956 ABK41939 BAA36564 BAA36565 BAA36566 BAA36567 BAA36568 BAA36569 BAA36570 BAA36571 BAA36572 BAA36573 BAA36574 BAA36575 BAA36576 BAF32756 BAF32757 BAF32758 CBH30554 P20273 AK026467 BAB15489 AK225625 AK225694 AK301177 BAH13422 BC109306 AAI09307 BC109307 BQ054599 CF138699 DA931592 DA989528 DB333800 X52785 CAA36988 X59350 CAA42006 NM_024916 NM_001185099 NP_001172028 NM_001185100 NP_001172029 NM_001185101 NP_001172030 NM_001278417 NP_001265346 NM_001771 NP_001762
Function	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	B-lymphocytes.
Top Pathways	Hematopoietic cell lineage, B cell receptor signaling pathway, Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse CD22 ELISA Kit (Sandwich ELISA) - LS-F2963 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 156-10000 pg/ml

Human CD22 ELISA Kit (Sandwich ELISA) - LS-F7153 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 1.14 ng/ml Range 156-10000 pg/ml

Human Phospho-CD22 (Tyr807) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1712 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 156-10000 pg/ml

Human CD22 ELISA Kit (Cell-Based ELISA) - LS-F1829 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 156-10000 pg/ml

B-cell receptor CD22 (CD22), Human, ELISA Kit - E01B0880 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

B-cell receptor CD22, CD22, Human, ELISA Kit - E1513h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Cluster of differentiation 22 (CD22), Human, ELISA Kit - CSB-E17496h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cluster of differentiation 22 (CD22), Human, ELISA Kit - E01C1471 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0pg/ml Range 100-2500pg/ml

Sialic Acid Binding Ig Like Lectin 2 (SIGLEC2), Human, ELISA Kit - SEB144Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.134ng/mL Range 0.312-20ng/mL

Sialic Acid Binding Immunoglobulin Like Lectin 2, SIGLEC2, Human, ELISA Kit - E-EL-H1321 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Sialic Acid Binding Ig Like Lectin 2, SIGLEC2, Rabbit, ELISA Kit - E-EL-RB0359 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 2, SIGLEC2, Chicken, ELISA Kit - E-EL-Ch1696 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 2, SIGLEC2, Porcine, ELISA Kit - E-EL-P1722 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 2, SIGLEC2, Monkey, ELISA Kit - E-EL-MK1101 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

BL-CAM Colorimetric Cell-Based ELISA Kit - CB5075 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

BL-CAM (Phospho-Tyr807) Colorimetric Cell-Based ELISA Kit - CBP1790 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human SIGLEC2(Sialic Acid Binding Immunoglobulin Like Lectin 2) ELISA Kit - E-EL-H1321 from Elabscience Category ELISA Kit Sensitivity 9.38 pg/mL Range 15.63—1000 pg/mL

Human SIGLEC2 (Sialic Acid Binding Ig Like Lectin 2) CLIA Kit - E-CL-H0865 from Elabscience Category CLIA Kit Sensitivity 7.50 pg/mL Range Average Recovery (%)

B-cell receptor CD22 (CD22), ELISA Kit - MBS7226668 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell receptor CD22 (CD22), ELISA Kit - MBS7221826 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell receptor CD22 (CD22), ELISA Kit - MBS7213414 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell receptor CD22 (CD22), ELISA Kit - MBS7213511 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell receptor CD22 (CD22), ELISA Kit - MBS7213521 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

CD22 molecule, ELISA Kit - MBS902049 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cluster of differentiation 22 (CD22), ELISA Kit - MBS7206185 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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