CD22

Gene Symbol CD22
Entrez Gene 933
Alt Symbol SIGLEC-2, SIGLEC2
Species Human
Gene Type protein-coding
Description CD22 molecule
Other Description B-cell receptor CD22|B-lymphocyte cell adhesion molecule|BL-CAM|CD22 antigen|T-cell surface antigen Leu-14|sialic acid binding Ig-like lectin 2|sialic acid-binding Ig-like lectin 2
Swissprots Q9UQA7 Q01665 Q32M46 F5GYU4 Q9Y2A6 O95699 P20273 Q9UQA6 O95702 O95703 F5H7U3 Q9UQB0 Q9UQA8 Q92872 Q92873 O95701 Q9UQA9
Accessions AAB06448 AAB06449 AAC18956 ABK41939 BAA36564 BAA36565 BAA36566 BAA36567 BAA36568 BAA36569 BAA36570 BAA36571 BAA36572 BAA36573 BAA36574 BAA36575 BAA36576 BAF32756 BAF32757 BAF32758 CBH30554 P20273 AK026467 BAB15489 AK225625 AK225694 AK301177 BAH13422 BC109306 AAI09307 BC109307 BQ054599 CF138699 DA931592 DA989528 DB333800 X52785 CAA36988 X59350 CAA42006 NM_024916 NM_001185099 NP_001172028 NM_001185100 NP_001172029 NM_001185101 NP_001172030 NM_001278417 NP_001265346 NM_001771 NP_001762
Function Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity B-lymphocytes.
Top Pathways Hematopoietic cell lineage, B cell receptor signaling pathway, Cell adhesion molecules (CAMs)

CD22 (D-5) - sc-271579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (D-5): sc-271579. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing cytoplasmic staining of cells in germinal and non-germinal centers.

CD22 (E-9) - sc-377304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (E-9): sc-377304. Western blot analysis of CD22 expression in BJAB (A) and Ramos (B) whole cell lysates.

CD22 (Y-19) - sc-7032 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of CD22 (CD22) expression in BJAB whole cell lysate (A,B). Antibodies tested include CD22 (Y-19): sc-7032 (A) and CD22 (MYG13): sc-7323 (B).

CD22 (HD239) - sc-18909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (HD239) PE: sc-18909 PE. FCM analysis of BJAB cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-2868.

CD22 (H-221) - sc-7932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD22 (H-221): sc-7932. Western blot analysis of CD22 expression in BJAB whole cell lysate.

CD22 (MYG13) - sc-7323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (MYG13) FITC: sc-7323 FITC. FCM analysis of BJAB cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

CD22 (RFB-4) - sc-7307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (RFB-4) FITC: sc-7307 FITC. FCM analysis of GA-10 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

CD22 (N-20) - sc-7031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD22 (N-20): sc-7031. Western blot analysis of CD22 (CD22) expression in BJAB whole cell lysate.

CD22 (4KB128) - sc-20053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (4KB128) FITC: sc-20053 FITC. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

CD22 (SJ10.1H11) - sc-18900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (SJ10.1H11) PE: sc-18900 PE. FCM analysis of GA-10 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

CD22 (48) - sc-136440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD22 (48): sc-136440. Western blot analysis of CD22 expression in Ramos whole cell lysate.

CD22 (37) - sc-136507 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

CD22 (HD39) - sc-73363 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-CD22 (phospho Y762) antibody [EP727Y] - ab45135 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP727Y

Anti-CD22 (phospho Y807) antibody - ab79369 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD22 (phospho Y807) antibody (ab79369) at 1/500 dilutionLane 1 : K562 cell extracts, treated with Na3VO4 (0.3nM, 40mins)Lane 2 : K562 cell extracts, treated with Na3VO4 (0.3nM, 40mins) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CD22 (phospho Y807) antibody [Y505] - ab32040 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y505
All lanes : Anti-CD22 (phospho Y807) antibody [Y505] (ab32040) at 1/2000 dilutionLane 1 : Raji Cell Lysate with UntreatedLane 2 : Raji Cell Lysate with Pervanadate

Anti-CD22 (phospho Y822) antibody [Y506] - ab32123 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y506
All lanes : Anti-CD22 (phospho Y822) antibody [Y506] (ab32123) at 1/1000 dilutionLane 1 : Untreated Raji cell lysateLane 2 : Raji cell lysate treated with Pervanadate

Anti-CD22 (phospho Y842) antibody [Y507] - ab32355 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y507
All lanes : Anti-CD22 (phospho Y842) antibody [Y507] (ab32355) at 1/2000 dilutionLane 1 : Raji Cell Lysate, UntreatedLane 2 : Raji Cell Lysate, Treated with PervanadateLysates/proteins at 10 µg per lane.

Anti-CD22 antibody - ab65852 from Abcam

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab65852, at 1µg/ml, staining Human CD22 in the cytoplasm of an appendicitis section, by Immunohistochemistry, Paraffin-embedded tissue.

Anti-CD22 antibody - ab25135 from Abcam

Prices $373.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD22 antibody - ab196888 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD22 antibody (ab196888) at 1/500 dilutionLane 1 : Extracts from 293 cells treated with Ca2+ (40nM, 40mins)Lane 2 : 293 cell extracts treated with Ca2+ (40nM, 40mins) with synthesized peptide

Anti-CD22 antibody [2H1C4] - ab181771 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H1C4
Anti-CD22 antibody [2H1C4] (ab181771) at 1/500 dilution + Human CD22 recombinant protein

Anti-CD22 antibody (Biotin) - ab84227 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CD22 antibody [EP498Y] - ab33859 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP498Y
Anti-CD22 antibody [EP498Y] (ab33859) at 1/1000 dilution + Raji cell lysate

Anti-CD22 antibody [FPC1], prediluted - ab1411 from Abcam

Prices $370.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone FPC1
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