| Gene Symbol | CD22 |
|---|---|
| Entrez Gene | 933 |
| Alt Symbol | SIGLEC-2, SIGLEC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD22 molecule |
| Other Description | B-cell receptor CD22|B-lymphocyte cell adhesion molecule|BL-CAM|CD22 antigen|T-cell surface antigen Leu-14|sialic acid binding Ig-like lectin 2|sialic acid-binding Ig-like lectin 2 |
| Swissprots | Q9UQA7 Q01665 Q32M46 F5GYU4 Q9Y2A6 O95699 P20273 Q9UQA6 O95702 O95703 F5H7U3 Q9UQB0 Q9UQA8 Q92872 Q92873 O95701 Q9UQA9 |
| Accessions | AAB06448 AAB06449 AAC18956 ABK41939 BAA36564 BAA36565 BAA36566 BAA36567 BAA36568 BAA36569 BAA36570 BAA36571 BAA36572 BAA36573 BAA36574 BAA36575 BAA36576 BAF32756 BAF32757 BAF32758 CBH30554 P20273 AK026467 BAB15489 AK225625 AK225694 AK301177 BAH13422 BC109306 AAI09307 BC109307 BQ054599 CF138699 DA931592 DA989528 DB333800 X52785 CAA36988 X59350 CAA42006 NM_024916 NM_001185099 NP_001172028 NM_001185100 NP_001172029 NM_001185101 NP_001172030 NM_001278417 NP_001265346 NM_001771 NP_001762 |
| Function | Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | B-lymphocytes. |
| Top Pathways | Hematopoietic cell lineage, B cell receptor signaling pathway, Cell adhesion molecules (CAMs) |