| Gene Symbol |
LYPLA1
|
| Entrez Gene |
10434
|
| Alt Symbol |
APT-1, APT1, LPL-I, LPL1, hAPT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophospholipase I
|
| Other Description |
acyl-protein thioesterase 1|lysoPLA I|lysophospholipid-specific lysophospholipase
|
| Swissprots |
O43202 Q9UQF9 O75608
|
| Accessions |
EAW86742 EAW86743 EAW86744 EAW86745 EAW86746 O75608 AA307642 AA827237 AF035293 AAB88180 AF052112 AF077198 AAD26993 AF077199 AAD26994 AF081281 AAC31610 AF291053 AAG10063 AK289400 BAF82089 AK298206 BAG60476 AK307277 AK313739 BAG36480 BC008652 AAH08652 BC010397 AAH10397 CR457103 CAG33384 DA817192 DA881616 DA883059 DQ891527 ABM82453 DQ894717 ABM85643 XM_005251127 XP_005251184 NM_001279356 NP_001266285 NM_001279357 NP_001266286 NM_001279358 NP_001266287 NM_001279359 NP_001266288 NM_001279360 NP_001266289 NM_006330 NP_006321
|
| Function |
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. {ECO:0000269|PubMed:20418879, ECO:0000269|PubMed:22399288}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Choline metabolism in cancer, Glycerophospholipid metabolism
|