Gene Symbol | TTC37 |
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Entrez Gene | 9652 |
Alt Symbol | KIAA0372, Ski3, THES |
Species | Human |
Gene Type | protein-coding |
Description | tetratricopeptide repeat domain 37 |
Other Description | SKI3 homolog|TPR repeat protein 37|tetratricopeptide repeat protein 37|thespin|tricho-hepatic-enteric syndrome protein |
Swissprots | O15077 Q6PGP7 Q6PJI3 |
Accessions | EAW96037 EAW96038 Q6PGP7 AB002370 BAA20827 AK307531 BC009767 BC015163 AAH15163 BC030966 BC056893 AAH56893 XR_948312 NM_014639 NP_055454 |
Function | Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16024656}. Nucleus {ECO:0000269|PubMed:16024656}. |
Tissue Specificity | Widely expressed with the highest levels observed in vascular tissues, lymph node, pituitary, lung and intestine. Not expressed in the liver. {ECO:0000269|PubMed:21120949}. |
Top Pathways | RNA degradation |
TTC37 CRISPR/Cas9 KO Plasmid (h) - sc-407756 from Santa Cruz Biotechnology
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TTC37 HDR Plasmid (h) - sc-407756-HDR from Santa Cruz Biotechnology
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TTC37 Double Nickase Plasmid (h) - sc-407756-NIC from Santa Cruz Biotechnology
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TTC37 Double Nickase Plasmid (h2) - sc-407756-NIC-2 from Santa Cruz Biotechnology
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TTC37 CRISPR Activation Plasmid (h) - sc-407756-ACT from Santa Cruz Biotechnology
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TTC37 CRISPR Activation Plasmid (h2) - sc-407756-ACT-2 from Santa Cruz Biotechnology
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TTC37 Lentiviral Activation Particles (h) - sc-407756-LAC from Santa Cruz Biotechnology
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TTC37 Lentiviral Activation Particles (h2) - sc-407756-LAC-2 from Santa Cruz Biotechnology
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TTC37 siRNA (h) - sc-91828 from Santa Cruz Biotechnology
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TTC37 shRNA Plasmid (h) - sc-91828-SH from Santa Cruz Biotechnology
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TTC37 shRNA (h) Lentiviral Particles - sc-91828-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22176 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22176 from Sigma-Aldrich
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TTC37 siRNA (Human) - CRH6429 from Cohesion Biosciences
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TTC37 - MBS8214911 from MyBioSource
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shRNA set against Human TTC37 (NM_014639.3) - SHH437088 from Creative biogene
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Human TTC37 siRNA - orb266931 from Biorbyt
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TTC37 shRNA Plasmid (Human) - CHH6429 from Cohesion Biosciences
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TTC37 miRNA 3'UTR clone - MiUTR3H-13322 from Creative biogene
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