| Gene Symbol |
CFC1
|
| Entrez Gene |
55997
|
| Alt Symbol |
CFC1B, CRYPTIC, DTGA2, HTX2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cripto, FRL-1, cryptic family 1
|
| Other Description |
cryptic family protein 1|cryptic protein|heterotaxy 2 (autosomal dominant)
|
| Swissprots |
P0CG37
|
| Accessions |
AAG42475 CCA65395 P0CG37 AF312769 AAG30294 AK290094 BAF82783 AK315326 BAG37727 BC069508 AAH69508 BC074825 AAH74825 BC074826 AAH74826 BC110080 AAI10081 BC146897 AAI46898 BG654700 BI793242 BM310214 BM509218 CA777249 CA941621 CA948246 DQ786275 XM_011511486 XP_011509788 NM_001270420 NP_001257349 NM_001270421 NP_001257350 NM_032545 NP_115934
|
| Function |
NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation. {ECO:0000269|PubMed:11062482}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18930707}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18930707}. Secreted {ECO:0000269|PubMed:18930707}. Note=Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI- signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
|