| Gene Symbol |
CYLD
|
| Entrez Gene |
1540
|
| Alt Symbol |
BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cylindromatosis (turban tumor syndrome)
|
| Other Description |
deubiquitinating enzyme CYLD|probable ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin specific peptidase like 2|ubiquitin thioesterase CYLD|ubiquitin thiolesterase CYLD|ubiquitin-specific-processing protease CYLD
|
| Swissprots |
O94934 Q9NZX9 Q7L3N6 Q96EH0 Q9NQC7
|
| Accessions |
CAH05327 CBL94219 CBL94220 EAW82768 EAW82769 EAW82770 EAW82771 EAW82772 EAW82773 Q9NQC7 AF161542 AAF29029 AJ250014 CAB93533 AK000187 AK024212 BAG51271 AK024348 BAG51293 AK056226 AK225202 AK292975 BAF85664 AK310832 AL050166 BC012342 AAH12342 BI458962 BX642061 DA157717 DA785459 DA940312 DB119480 FN823255 CBL94217 FN823256 CBL94218 XM_005255812 XP_005255869 XM_006721149 XP_006721212 XM_011522906 XP_011521208 XM_011522907 XP_011521209 XM_011522908 XP_011521210 XM_011522909 XP_011521211 XM_011522910 XP_011521212 XM_011522911 XP_011521213 XR_933218 NM_001042355 NP_001035814 NM_001042412 NP_001035877 NM_015247 NP_056062
|
| Function |
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-k
|
| Subcellular Location |
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25134987}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25134987}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80TQ2}. Note=Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. During metaphase, it remains localized to the centrosome but is also present along the spindle (PubMed:25134987). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:25134987}.
|
| Tissue Specificity |
Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. {ECO:0000269|PubMed:10835629}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway, Osteoclast differentiation
|
![Immunofluorescence of monoclonal antibody to CYLD on HeLa cell . [antibody concentration 10 ug/ml]](http://www.bioprodhub.com/system/product_images/ab_products/3/sub_2/7080_144478_35860.jpg)
![Western Blot: CYLD Antibody [NB110-95574] - Detection of CYLD in Jurkat whole cell extract using NB110-95574.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_7/13113_CYLD-Antibody-Western-Blot-NB110-95574-img0003.jpg)
![Immunocytochemistry/Immunofluorescence: CYLD Antibody [NBP2-33589] - Staining of human cell line A-431 shows localization to microtubule organizing center.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_9/4393_CYLD-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-33589-img0003.jpg)
![Immunocytochemistry/Immunofluorescence: CYLD Antibody (2C3) [H00001540-M01] - Analysis of monoclonal antibody to CYLD on HeLa cell. Antibody concentration 10 ug/ml.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/10007_CYLD-Antibody-(2C3)-Immunocytochemistry-Immunofluorescence-H00001540-M01-img0004.jpg)