| Gene Symbol |
PSMB7
|
| Entrez Gene |
5695
|
| Alt Symbol |
Z
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) subunit, beta type, 7
|
| Other Description |
macropain chain Z|multicatalytic endopeptidase complex chain Z|proteasome catalytic subunit 2|proteasome subunit Z|proteasome subunit alpha|proteasome subunit beta type-7
|
| Swissprots |
Q5TBG6 Q9BWA7 B4E0P1 Q96AG8 Q99436
|
| Accessions |
EAW87582 EAW87583 Q99436 AJ420455 AK056654 AK098757 AK223007 BAD96727 AK223356 BAD97076 AK303460 BAG64503 AK308756 AK314302 BAG36956 BC000509 AAH00509 BC008414 BC017116 AAH17116 BT007218 AAP35882 CR456721 CAG33002 D38048 BAA07238 GU727627 ADU87629 U44425 AAD45962 NM_002799 NP_002790
|
| Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809, ECO:0000269|PubMed:18549262}. Nucleus {ECO:0000269|PubMed:18549262}.
|
| Tissue Specificity |
Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues. {ECO:0000269|PubMed:18549262}.
|
| Top Pathways |
Proteasome
|