Gene Symbol | Fscn2 |
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Entrez Gene | 238021 |
Alt Symbol | A930022G03, C630046B20Rik, ahl8 |
Species | Mouse |
Gene Type | protein-coding |
Description | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) |
Other Description | fascin-2|retinal fascin |
Swissprots | Q32M02 Q8BWU0 |
Accessions | EDL34739 Q32M02 AK044556 AK050002 BAC34026 AK078674 BB279997 BC109356 AAI09357 BC109357 AAI09358 XM_006533259 XP_006533322 NM_172802 NP_766390 |
Function | Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links. {ECO:0000269|PubMed:20660251}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20660251}. Cell projection, stereocilium {ECO:0000269|PubMed:20660251}. Note=Found mostly in longer hair- cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips. |
Tissue Specificity | Expressed in the inner ear. |
Fascin 2 CRISPR/Cas9 KO Plasmid (m) - sc-433603 from Santa Cruz Biotechnology
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Fascin 2 HDR Plasmid (m) - sc-433603-HDR from Santa Cruz Biotechnology
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Fascin 2 Double Nickase Plasmid (m) - sc-433603-NIC from Santa Cruz Biotechnology
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Fascin 2 Double Nickase Plasmid (m2) - sc-433603-NIC-2 from Santa Cruz Biotechnology
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Fascin 2 CRISPR Activation Plasmid (m) - sc-433603-ACT from Santa Cruz Biotechnology
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Fascin 2 CRISPR Activation Plasmid (m2) - sc-433603-ACT-2 from Santa Cruz Biotechnology
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Fascin 2 Lentiviral Activation Particles (m) - sc-433603-LAC from Santa Cruz Biotechnology
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Fascin 2 Lentiviral Activation Particles (m2) - sc-433603-LAC-2 from Santa Cruz Biotechnology
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Fascin 2 siRNA (m) - sc-44616 from Santa Cruz Biotechnology
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Fascin 2 shRNA Plasmid (m) - sc-44616-SH from Santa Cruz Biotechnology
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Fascin 2 shRNA (m) Lentiviral Particles - sc-44616-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU062101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31568 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31568 from Sigma-Aldrich
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FSCN2 siRNA (Mouse) - CRN3353 from Cohesion Biosciences
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FSCN2 - MBS8229476 from MyBioSource
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shRNA set against Mouse Fscn2 (NM_172802.4) - SHH297325 from Creative biogene
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Mouse FSCN2 siRNA - orb292828 from Biorbyt
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FSCN2 shRNA Plasmid (Mouse) - CHN3353 from Cohesion Biosciences
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