| Gene Symbol |
Grin1
|
| Entrez Gene |
24408
|
| Alt Symbol |
GluN1, NMDAR1, NR1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, ionotropic, N-methyl D-aspartate 1
|
| Other Description |
N-methyl-D-aspartate glutamate receptor|N-methyl-D-aspartate receptor subunit NR1|NMD-R1|NMDA R1 receptor C1 cassette|glutamate [NMDA] receptor subunit zeta-1|glutamate receptor ionotropic, NMDA 1|neurotransmitter receptor
|
| Swissprots |
P35439 Q62646
|
| Accessions |
EDL93606 EDL93607 EDL93608 EDL93609 EDL93610 EDL93611 EDL93612 EDL93613 P35439 AY090615 AAM09025 FM039130 S39221 AAB22435 U08261 AAB50926 U08262 AAB50927 U08263 AAB50928 U08264 AAB50929 U08265 AAB50930 U08266 AAB50931 U08267 AAB50932 U08268 AAB50933 U11418 AAA19659 X63255 CAA44914 X65227 CAA46335 XM_006233555 XP_006233617 XM_006233556 XP_006233618 NM_001270602 NP_001257531 NM_001270603 NP_001257532 NM_001270605 NP_001257534 NM_001270606 NP_001257535 NM_001270608 NP_001257537 NM_001270610 NP_001257539 NM_001287423 NP_001274352 NM_017010 NP_058706
|
| Function |
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. {ECO:0000269|PubMed:15996549}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO:0000250}.
|
| Top Pathways |
Amphetamine addiction, Circadian entrainment, cAMP signaling pathway, Alcoholism, Rap1 signaling pathway
|