NUMB

Gene Symbol NUMB
Entrez Gene 8650
Alt Symbol C14orf41, S171, c14_5527
Species Human
Gene Type protein-coding
Description numb homolog (Drosophila)
Other Description h-Numb|protein numb homolog
Swissprots B1P2N6 B1P2N9 B1P2N8 B4E2B1 Q6NUQ7 Q86SY1 B1P2N5 B1P2N7 Q9UEQ4 Q9UKE9 Q9UQJ4 Q9UKF0 Q9UBG1 Q9UKE8 P49757 Q8WW73
Accessions AAC97962 EAW81100 EAW81101 EAW81102 EAW81103 EAW81104 EAW81105 EAW81106 EAW81107 EAW81108 EAW81109 EAW81110 EAW81111 EAW81112 EAW81113 EAW81114 P49757 AA872908 AF015040 AAD01548 AF108092 AAD27959 AF171938 AAD54279 AF171939 AAD54280 AF171940 AAD54281 AF171941 AAD54282 AK023670 AK055876 AK226069 AK294591 BAG57779 AK300602 BAG62299 AK304193 BAG65073 AK315130 BAG37583 BC020788 AAH20788 BC033824 AAH33824 BC068476 AAH68476 BG654811 BX248073 CAD62362 BX248775 CAD66582 BX248781 CAD66588 BX647137 EU265734 ABY89090 EU265735 ABY89091 EU265736 ABY89092 EU265737 ABY89093 EU265738 ABY89094 JF432783 ADZ16000 L40393 AAC42000 XM_005268142 XP_005268199 XM_005268144 XP_005268201 XM_005268145 XP_005268202 XM_005268146 XP_005268203 XM_011537253 XP_011535555 XM_011537254 XP_011535556 XM_011537255 XP_011535557 XM_011537256 XP_011535558 XM_011537257 XP_011535559 XM_011537258 XP_011535560 XM_011537259 XP_011535561 XM_011537260 XP_011535562 XM_011537261 XP_011535563 XM_011537262 XP_011535564 XM_011537263 XP_011535565 XM_011537264 XP_011535566 NM_001005743 NP_001005743 NM_001005744 NP_001005744 NM_001005745 NP_001005745 NM_003744 NP_003735
Function Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Subcellular Location Membrane; Peripheral membrane protein.
Top Pathways Notch signaling pathway

NUMB CRISPR/Cas9 KO Plasmid (h) - sc-401673 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB HDR Plasmid (h) - sc-401673-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB Double Nickase Plasmid (h) - sc-401673-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB Double Nickase Plasmid (h2) - sc-401673-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB CRISPR Activation Plasmid (h) - sc-401673-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB CRISPR Activation Plasmid (h2) - sc-401673-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB Lentiviral Activation Particles (h) - sc-401673-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB Lentiviral Activation Particles (h2) - sc-401673-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NUMB siRNA (h) - sc-42146 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NUMB shRNA Plasmid (h) - sc-42146-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NUMB shRNA (h) Lentiviral Particles - sc-42146-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Numb RNAi - H00008650-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU074891 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15615 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15615 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09358 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09358

NUMB siRNA (Human) - CRH5688 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Numb RNAi - H00008650-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Numb RNAi - H00008650-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Numb RNAi - H00008650-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human NUMB (NM_003744.5) - SHH356316 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NUMB(NM_003744.5) - SHR026392 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NUMB(NM_001005744.1) - SHR026580 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NUMB(NM_001005745.1) - SHR026652 from Creative biogene

Category siRNA
Species Reactivities Human

Human NUMB siRNA - orb266190 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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