NUMB

Gene Symbol NUMB
Entrez Gene 8650
Alt Symbol C14orf41, S171, c14_5527
Species Human
Gene Type protein-coding
Description numb homolog (Drosophila)
Other Description h-Numb|protein numb homolog
Swissprots B1P2N6 B1P2N9 B1P2N8 B4E2B1 Q6NUQ7 Q86SY1 B1P2N5 B1P2N7 Q9UEQ4 Q9UKE9 Q9UQJ4 Q9UKF0 Q9UBG1 Q9UKE8 P49757 Q8WW73
Accessions AAC97962 EAW81100 EAW81101 EAW81102 EAW81103 EAW81104 EAW81105 EAW81106 EAW81107 EAW81108 EAW81109 EAW81110 EAW81111 EAW81112 EAW81113 EAW81114 P49757 AA872908 AF015040 AAD01548 AF108092 AAD27959 AF171938 AAD54279 AF171939 AAD54280 AF171940 AAD54281 AF171941 AAD54282 AK023670 AK055876 AK226069 AK294591 BAG57779 AK300602 BAG62299 AK304193 BAG65073 AK315130 BAG37583 BC020788 AAH20788 BC033824 AAH33824 BC068476 AAH68476 BG654811 BX248073 CAD62362 BX248775 CAD66582 BX248781 CAD66588 BX647137 EU265734 ABY89090 EU265735 ABY89091 EU265736 ABY89092 EU265737 ABY89093 EU265738 ABY89094 JF432783 ADZ16000 L40393 AAC42000 XM_005268142 XP_005268199 XM_005268144 XP_005268201 XM_005268145 XP_005268202 XM_005268146 XP_005268203 XM_011537253 XP_011535555 XM_011537254 XP_011535556 XM_011537255 XP_011535557 XM_011537256 XP_011535558 XM_011537257 XP_011535559 XM_011537258 XP_011535560 XM_011537259 XP_011535561 XM_011537260 XP_011535562 XM_011537261 XP_011535563 XM_011537262 XP_011535564 XM_011537263 XP_011535565 XM_011537264 XP_011535566 NM_001005743 NP_001005743 NM_001005744 NP_001005744 NM_001005745 NP_001005745 NM_003744 NP_003735
Function Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Subcellular Location Membrane; Peripheral membrane protein.
Top Pathways Notch signaling pathway

Phospho-Numb (Ser276) (D5C2) Rabbit mAb - 9878 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5C2
Western blot analysis of extracts from HeLa and U-87 MG cells, untreated or treated with either λ phosphatase or TPA #4174 (200 nM, 30 min), using Phospho-Numb (Ser276) (D5C2) Rabbit mAb (upper) or Numb (C29G11) Rabbit mAb #2756 (lower).

Phospho-Numb (Ser276) Antibody - 4140 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Ramos and HeLa cells, untreated or treated with TPA (Phorbol-12-Myristate-13-Acetate, 200 nM for 30 min) or λ-phosphatase, using Phospho-Numb (Ser276) Antibody (upper) or Numb (C29G11) Rabbit mAb #2756 (lower).

Numb Antibody - 2733 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from A204 and SK-OV-3 cells, using Numb Antibody.

Numb (C44B4) Rabbit mAb - 2761 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C44B4
Western blot analysis of extracts from HeLa and SK-OV-3 cells using Numb (C44B4) Rabbit mAb.

Numb (C29G11) Rabbit mAb - 2756 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C29G11
Western blot analysis of extracts from various cell lines using Numb (C29G11) Rabbit mAb.

NUMB (48) - sc-136554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NUMB (48): sc-136554. Western blot analysis of NUMB expression in rat brain tissue extract.

NUMB (H-70) - sc-25668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NUMB (H-70): sc-25668. Western blot analysis of NUMB expression in T98G whole cell lysate.

NUMB (N-20) - sc-15588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NUMB (N-20): sc-15588. Western blot analysis of NUMB expression in HEK293 (A), HeLa (B) and NIH/3T3 (C) whole cell lysates and mouse lung tissue extract (D).

NUMB (P-20) - sc-15590 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NUMB (P-20): sc-15590. Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing membrane localization.

Anti-NUMB antibody - ab14140 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab14140 staining NUMB in Zebrafish embryo nervous system by Immunohistochemistry (Whole mount). Samples were incubated with primary antibody (1/500 in BSA blocking buffer) for 48 hours at 4°C. An Alexa Fluor®488-conjugated Goat anti-rabbit  polyclonal (1/500) was used as the secondary antibody.See Abreview

Anti-NUMB antibody [1A7] - ab123891 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A7
All lanes : Anti-NUMB antibody [1A7] (ab123891) at 1/2000 dilutionLane 1 : lysate from HEK293T cells transfected with the pCMV6-ENTRY control cDNALane 2 : lysate from HEK293T cells transfected with the pCMV6-ENTRY NUMB cDNALysates/proteins at 5 µg per lane.

Anti-NUMB antibody [5A9] - ab139157 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5A9
All lanes : Anti-NUMB antibody [5A9] (ab139157) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY NUMB cDNALysates/proteins at 5 µg per lane.

Anti-NUMB antibody [EPR3551(N)] - N-terminal - ab177465 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3551(N)
All lanes : Anti-NUMB antibody [EPR3551(N)] - N-terminal (ab177465) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Ramos cell lysateLane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat-anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-NUMB antibody - C-terminal - ab135059 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-NUMB antibody - C-terminal (ab135059) at 1/1000 dilutionLane 1 : HeLa lysate Lane 2 : MEF lysate SecondaryLane 2 : Rabbit polyclonal to NUMB - C-terminal (ab135059) at 1/5000 dilution

Anti-NUMB Antibody (clone 4F3) - LS-C172507 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F3
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-NUMB mouse monoclonal antibody.

Anti-NUMB Antibody (aa1-365, clone 3B2) - LS-C338542 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NUMB (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NUMB.

Anti-NUMB Antibody (aa1-365, clone 5C5) - LS-C338545 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NUMB (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NUMB.

Anti-NUMB Antibody (aa1-365, clone 4H2) - LS-C338547 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NUMB (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NUMB.

Anti-NUMB Antibody (aa1-365, clone 3H8) - LS-C338541 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H8
IHC of paraffin-embedded Human embryonic cerebellum using anti-NUMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).

Anti-NUMB Antibody (aa1-365, clone 1B5) - LS-C338539 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B5
IHC of paraffin-embedded Human muscle tissue using anti-NUMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-NUMB Antibody (aa1-50) IHC-plus™ - LS-B8003 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NUMB antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8003 concentration 10 ug/ml.

Anti-NUMB Antibody (aa1-365, clone 3E5) - LS-C336481 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E5
IHC of paraffin-embedded Human muscle tissue using anti-NUMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-NUMB Antibody (aa1-365, clone 2E8) - LS-C336477 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E8
IHC of paraffin-embedded Human melanoma tissue using anti-NUMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-NUMB Antibody (clone 5A9) - LS-C172381 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 5A9
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-NUMB mouse monoclonal antibody.

Anti-NUMB Antibody (aa538-557) - LS-C9376 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
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