Gene Symbol | RXRB |
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Entrez Gene | 6257 |
Alt Symbol | DAUDI6, H-2RIIBP, NR2B2, RCoR-1 |
Species | Human |
Gene Type | protein-coding |
Description | retinoid X receptor, beta |
Other Description | MHC class I promoter binding protein|nuclear receptor subfamily 2 group B member 2|retinoic acid receptor RXR-beta |
Swissprots | Q5JP92 Q5STQ1 P28702 Q59G65 P28703 |
Accessions | AAC18599 AAD13794 CAA20239 CAI95622 EAX03679 P28702 AB209244 BAD92481 AK225842 AK295759 BAH12180 AK300402 BAH13278 AK301096 BAH13409 AK302125 BAH13631 AW473828 BC001167 AAH01167 BE704198 BM982876 BT007280 AAP35944 DC425042 HQ692844 ADZ17355 HQ709179 ADZ17386 M84820 AAA60293 X63522 CAA45087 X63523 X65463 CAA46456 X66424 XM_005249278 XP_005249335 XM_005249279 XP_005249336 XM_005272854 XP_005272911 XM_005272855 XP_005272912 XM_005275007 XP_005275064 XM_005275008 XP_005275065 XM_005275149 XP_005275206 XM_005275150 XP_005275207 XM_005275276 XP_005275333 XM_005275277 XP_005275334 XM_005275438 XP_005275495 XM_005275439 XP_005275496 XM_011514796 XP_011513098 XM_011547269 XP_011545571 XM_011547672 XP_011545974 XM_011547899 XP_011546201 XM_011548071 XP_011546373 XM_011548260 XP_011546562 XR_926297 XR_952211 XR_952639 XR_952836 XR_952946 XR_953009 NM_001270401 NP_001257330 NM_001291989 NP_001278918 NM_021976 NP_068811 |
Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed in a variety of tumor cell lines. {ECO:0000269|PubMed:8381386}. |
Top Pathways | Small cell lung cancer, Non-small cell lung cancer, Adipocytokine signaling pathway, PPAR signaling pathway, Thyroid cancer |
RXRβ siRNA (h) - sc-36445 from Santa Cruz Biotechnology
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RXRβ shRNA Plasmid (h) - sc-36445-SH from Santa Cruz Biotechnology
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RXRβ shRNA (h) Lentiviral Particles - sc-36445-V from Santa Cruz Biotechnology
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RXRβ siRNA (h2) - sc-38874 from Santa Cruz Biotechnology
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RXRβ shRNA Plasmid (h2) - sc-38874-SH from Santa Cruz Biotechnology
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RXRβ shRNA (h2) Lentiviral Particles - sc-38874-V from Santa Cruz Biotechnology
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RXR beta/NR2B2 RNAi - H00006257-R01 from Novus Biologicals
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MISSION® esiRNA - EHU219951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18774 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18774 from Sigma-Aldrich
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RXRB siRNA (Human) - CRH4213 from Cohesion Biosciences
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RXRB - MBS8220855 from MyBioSource
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shRNA set against Human RXRB (NM_021976.4) - SHH400984 from Creative biogene
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Human RXRB siRNA - orb264715 from Biorbyt
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RXRB shRNA Plasmid (Human) - CHH4213 from Cohesion Biosciences
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RXRB miRNA 3'UTR clone - MiUTR3H-02033 from Creative biogene
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