| Gene Symbol | UCHL5 |
|---|---|
| Entrez Gene | 51377 |
| Alt Symbol | CGI-70, INO80R, UCH-L5, UCH37 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin carboxyl-terminal hydrolase L5 |
| Other Description | INO80 complex subunit R|ubiquitin C-terminal hydrolase UCH37|ubiquitin carboxyl-terminal esterase L5|ubiquitin carboxyl-terminal hydrolase isozyme L5|ubiquitin thioesterase L5 |
| Swissprots | Q5LJA6 Q8TBS4 Q9Y5K5 Q9UQN2 Q9H1W5 Q96BJ9 Q9P0I3 Q5LJA7 |
| Accessions | EAW91233 EAW91234 EAW91235 EAW91236 EAW91237 EAW91238 Q9Y5K5 AF147717 AAD31528 AF151828 AAD34065 AF157320 AAF67486 AK024751 AK123655 AK225794 AK296487 BAG59125 AK301381 BAG62921 AK314445 BAG37054 AK316064 BAH14435 BC015381 BC015521 AAH15521 BC025369 AAH25369 BI548319 BT006790 AAP35436 DA255130 JF432659 ADZ15876 XM_005245244 XP_005245301 XM_005245245 XP_005245302 XM_005245246 XP_005245303 XM_005245247 XP_005245304 XM_005245248 XP_005245305 XM_005245249 XP_005245306 XM_006711366 XP_006711429 XM_006711367 XP_006711430 XM_006711368 XP_006711431 XM_006711369 XP_006711432 XM_006711370 XP_006711433 XM_006711371 XP_006711434 XM_011509604 XP_011507906 XM_011509605 XP_011507907 XM_011509606 XP_011507908 XM_011509607 XP_011507909 XM_011509608 XP_011507910 XM_011509609 XP_011507911 XR_921823 NM_001199261 NP_001186190 NM_001199262 NP_001186191 NM_001199263 NP_001186192 NM_015984 NP_057068 NR_037607 |
| Function | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18922472}. Nucleus {ECO:0000269|PubMed:18922472}. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus. |
UCH-L5 CRISPR/Cas9 KO Plasmid (h) - sc-416520 from Santa Cruz Biotechnology
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UCH-L5 HDR Plasmid (h) - sc-416520-HDR from Santa Cruz Biotechnology
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UCH-L5 Double Nickase Plasmid (h) - sc-416520-NIC from Santa Cruz Biotechnology
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UCH-L5 Double Nickase Plasmid (h2) - sc-416520-NIC-2 from Santa Cruz Biotechnology
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UCH-L5 CRISPR Activation Plasmid (h) - sc-416520-ACT from Santa Cruz Biotechnology
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UCH-L5 CRISPR Activation Plasmid (h2) - sc-416520-ACT-2 from Santa Cruz Biotechnology
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UCH-L5 Lentiviral Activation Particles (h) - sc-416520-LAC from Santa Cruz Biotechnology
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UCH-L5 Lentiviral Activation Particles (h2) - sc-416520-LAC-2 from Santa Cruz Biotechnology
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UCH-L5 siRNA (h) - sc-76797 from Santa Cruz Biotechnology
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UCH-L5 shRNA Plasmid (h) - sc-76797-SH from Santa Cruz Biotechnology
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UCH-L5 shRNA (h) Lentiviral Particles - sc-76797-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU049401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22436 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22436 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04240 from Sigma-Aldrich
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UCHL5 siRNA (Human) - CRH9733 from Cohesion Biosciences
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UCHL5 - MBS8209395 from MyBioSource
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shRNA set against Human UCHL5 (NM_015984.3) - SHH439781 from Creative biogene
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UCHL5 shRNA Plasmid (Human) - CHH9733 from Cohesion Biosciences
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UCHL5 miRNA 3'UTR clone - MiUTR3H-11403 from Creative biogene
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