Gene Symbol | SLC25A36 |
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Entrez Gene | 55186 |
Alt Symbol | PNC2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 |
Other Description | solute carrier family 25 (pyrimidine nucleotide carrier ), member 36|solute carrier family 25 member 36|solute carrier family 25, member 36 |
Swissprots | Q9H0G8 Q9NVN5 A8MYF7 Q05CY1 Q96CQ1 |
Accessions | EAW79011 EAW79012 EAW79013 Q96CQ1 AK001480 BAA91715 AK296785 BAG59363 AL049246 AL136803 CAB66737 BC014064 AAH14064 BC019859 BC036272 BM552452 BQ718950 BQ771812 DA593079 EU831411 ACE87098 EU831504 ACE86423 XM_005247575 XP_005247632 XM_006713685 XP_006713748 XM_011512951 XP_011511253 XM_011512952 XP_011511254 XM_011512953 XP_011511255 XR_924150 XR_924151 XR_924152 XR_924153 XR_924154 XR_924155 XR_924156 XR_924157 NM_001104647 NP_001098117 NM_018155 NP_060625 |
Function | Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. {ECO:0000269|PubMed:25320081}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000305|PubMed:25320081}; Multi-pass membrane protein {ECO:0000255}. |
Tissue Specificity | Expressed at moderate level. {ECO:0000269|PubMed:17210862}. |
SLC25A36 CRISPR/Cas9 KO Plasmid (h) - sc-412475 from Santa Cruz Biotechnology
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SLC25A36 HDR Plasmid (h) - sc-412475-HDR from Santa Cruz Biotechnology
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SLC25A36 Double Nickase Plasmid (h) - sc-412475-NIC from Santa Cruz Biotechnology
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SLC25A36 Double Nickase Plasmid (h2) - sc-412475-NIC-2 from Santa Cruz Biotechnology
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SLC25A36 CRISPR Activation Plasmid (h) - sc-412475-ACT from Santa Cruz Biotechnology
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SLC25A36 CRISPR Activation Plasmid (h2) - sc-412475-ACT-2 from Santa Cruz Biotechnology
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SLC25A36 Lentiviral Activation Particles (h) - sc-412475-LAC from Santa Cruz Biotechnology
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SLC25A36 Lentiviral Activation Particles (h2) - sc-412475-LAC-2 from Santa Cruz Biotechnology
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SLC25A36 siRNA (h) - sc-78221 from Santa Cruz Biotechnology
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SLC25A36 shRNA Plasmid (h) - sc-78221-SH from Santa Cruz Biotechnology
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SLC25A36 shRNA (h) Lentiviral Particles - sc-78221-V from Santa Cruz Biotechnology
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SLC25A36 RNAi - H00055186-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19506 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19506 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06596 from Sigma-Aldrich
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SLC25A36 siRNA (Human) - CRJ0538 from Cohesion Biosciences
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SLC25A36 - MBS8215548 from MyBioSource
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shRNA set against Human SLC25A36 (NM_018155.2) - SHH409728 from Creative biogene
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shRNA set against Human SLC25A36(NM_018155.2) - SHL003592 from Creative biogene
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Human SLC25A36 siRNA - orb271039 from Biorbyt
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SLC25A36 shRNA Plasmid (Human) - CHJ0538 from Cohesion Biosciences
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SLC25A36 miRNA 3'UTR clone - MiUTR1H-09485 from Creative biogene
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