| Gene Symbol |
SLC38A4
|
| Entrez Gene |
55089
|
| Alt Symbol |
ATA3, NAT3, PAAT, SNAT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 38, member 4
|
| Other Description |
N amino acid transporter 3|Na(+)-coupled neutral amino acid transporter 4|amino acid transporter A3|amino acid transporter system A3|sodium-coupled neutral amino acid transporter 4|system A amino acid transporter 3|system N amino acid transporter 3
|
| Swissprots |
A8K553 Q969I6
|
| Accessions |
CAD20438 EAW57917 EAW57918 EAW57919 EAW57920 Q969I6 AB055003 BAB84090 AF193836 AAK71508 AF305814 AAK43528 AK001053 BAA91481 AK291168 BAF83857 BC069819 AAH69819 BC101827 AAI01828 BC104913 AAI04914 CB164010 DB139964 XM_005268997 XP_005269054 NM_001143824 NP_001137296 NM_018018 NP_060488
|
| Function |
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}; Multi-pass membrane protein {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}.
|
| Tissue Specificity |
Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels. {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}.
|